January 2015
A review on novel therapies to combat hepatitis C
The major cause of chronic liver disease, cirrhosis, liver carcinoma and liver failure is Hepatitis C virus (HCV). NS3 is one of the attractive targets for therapy development for HCV as the N-terminal domain of the NS3 protein is a serine protein. NS3 protease acts by interfering with cellular mechanisms which are involved in the host immune response to an HCV infection and the inhibition of the protease is...
January 2015
Determination of the abortifacient activity of the aqueous extract of Phytolacca dodecandra (L’Her) leaf in Wistar rats
Throughout history women have tried to control their fertility using herbal remedies; traditionally Phytolacca dodecandra leaves have been used as an abortifacient. The objective of this study was to determine the abortifacient activity of the aqueous extract of P. dodecandra leaf in Wistar rats. Hundred grams of shaded dried powdered leaves were soaked in 0.5 L of cold water, and using cold maceration, an aqueous...
January 2015
Analysis of rational use of drugs as of facility indicators and patient care indicators practices at four selected hospitals of West Ethiopia: Policy implication
The international network for rational use of drugs comprises a set of indicators called "drug use indicators" that can be used to assess rational drug use by the patient, health professionals and drug use managements at facility level. These indicators comprise of: Prescribing indicators, patient care indicators and facility indicators. A cross-sectional descriptive study has been conducted to collect the...
January 2015
Anxiolytic properties of Melissa officinalis and associated mechanisms of action: A review of the literature
The anxiety disorders prevalence has significantly increased in society. These disorders can be treated with anxiolytics which, despite great efficacy, may result in several adverse side effects. Several studies have reported that anxiolytic effects result from the indirect action on the GABAergic system and mechanisms related to the cholinergic system. Melissa officinalis has been widely utilized for its sedative...
January 2015
Effect of Citrus paradisi and Citrus sinensis on glycemic control in rats
This study was conducted to explore the effects of Citrus sinensis (orange juice) and Citrus paradisi (grapefruit juice) at three different doses alone and their two combinations on plasma insulin and blood glucose levels in healthy and diabetic rats. Diabetes was induced by alloxan after which rats were treated with C. sinensis and C. paradisi juices for six weeks, blood glucose and plasma insulin concentration was...
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