African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 22 June, 2013; 7(23)

June 2013

New vitality of ancient ethnomedicine in China: Review of Li ethnomedicine

Nowadays, with the development of nature drug, herbal medicine is gaining more attention from scientists in various countries. In China, ancient ethnomedicine based on natural medicinal plants faces new opportunities and challenges. This paper examines Li ethnomedicine, which has not attracted much attention among researchers yet. Four special species, which had important significance for modern research and were very...

Author(s): Yuanyuan Yu, Hao Hu, Meiwan Chen and Yitao Wang

June 2013

Antidiarrheal and antidiabetic effect of ethanol extract of whole Ageratum conyzoides L. in albino rat model

Ageratum conyzoides L. (Asteraceae) is a medicinal herb widely used for several diseases although data are unavailable for diarrhea and diabetes. This study investigated the efficacy of orally administrated ethanol extract of A. conyzoides L. on diarrheal and diabetic rat models. Castor oil induced diarrheal model and gastrointestinal motility test models (barium sulfate milk and charcoal suspension) of...

Author(s): Md. Atiar Rahman, Rabeya Sultana, Rasheda Akter and Md. Shahidul Islam

June 2013

Analgesic and anti-inflammatory activities of the ethanol extract of Taxillus sutchuenensis in mice

In this study, the analgesic activities and the mechanism of anti-inflammatory activities of 50% ethanol extract from TS (ETS) in vivo were investigated. Investigations were performed in mice with 2 analgesic models: acetic acid-induced writhing response and formalin-induced paw licking. The anti-inflammatory effect was tested by λ-carrageenan (Carr)-induced mice paw edema. These analgesic results...

Author(s): Chia-Yu Liu, Yung-Jia Chiu, Lung-Yuan Wu, Chao-Lin Kuo and Wen-Huang Peng

June 2013

Ameliorating effect of Withania somnifera on acephate administered male albino rats

This study was performed to investigate the effects of Withania somnifera (family: Solanaceae) on the antioxidant status and hormonal level in acephate administered rats. Oral administration of acephate (75 mg/kg body weight/day) for 15 and 30 days caused a significant decrease in serum testosterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) concentration when compared with control group....

Author(s): Nakuleshwar Dut Jasuja, Preeti Sharma and Suresh C. Joshi

June 2013

A comprehensive effect of acephate on cauda epididymis and accessory sex organs of male rats

In the present study, thirty six (36) adult male Wistar rats were divided into six groups each containing 6 Wistar rats (n = 6). Group I served as untreated control group while group II served as the positive control and group III served as the negative control. Group IV, V and VI were considered as the experimental groups. Group II received tetracyclin (28.6 mg/kg/b.wt/day), while group III received vehicle (olive...

Author(s): Nakuleshwar Dut Jasuja, Preeti Sharma and Suresh C. Joshi

June 2013

In vivo assessment of antihyperglycemic and antioxidant activity from oil of linseed in streptozotocin induced diabetic rats

In the present study, the antihyperglycemic and antioxidant effects of oil from seeds of Linum usitatissimum Linn. (LO) were investigated. A streptozotocin-nicotinamide (STZ) rat model of hyperglycaemia was used to evaluate the antihyperglycemic and antioxidant properties of oil of linseed. The body weight, oral glucose tolerance test and biochemical parameters namely;...

Author(s): Manoj Kumar, Sunil Sharma and Neeru Vasudeva

June 2013

Inhibitory effects of methanolic extracts of two eggplant species from South-western Nigeria on starch hydrolysing enzymes linked to type-2 diabetes

This study sought to investigate the inhibitory effect of methanolic extract of different species of African eggplant (Solanum melongena L.) and (Solanum macrocarpon) on starch hydrolysing enzymes relevant to type-2 diabetes (α-amylase and α-glucosidase). The phenolic content and antioxidant properties of the eggplant varieties were also assessed. The results revealed that both extracts exhibited mild...

Author(s): Esther E. Nwanna, Emmanuel O. Ibukun and Ganiyu Oboh

June 2013

Effects of administration of carbamazepine and/or phenytoin on haematological parameters in wistar rats

The aim of the study was to evaluate the haematological alterations following the administration of carbamazepine (CBZ) and/or phenytoin (PHE). Forty apparently, healthy male adult Wistar rats weighing between 144 and 300 g were used for the experiment. They were divided into four groups of 10 animals each. Rats in group I (controls) were given distilled water at the dose of 2 ml/kg and they served as untreated...

Author(s): Hadiza Aliyu, Joseph O. Ayo, Suleiman F. Ambali, and Abdulkadir U. Zezi

June 2013

Formulation and in vitro evaluation of antineoplastic drug loaded nanoparticles as drug delivery system

The main aim of the present work was to formulate anti-neoplastic drug loaded polymeric nanoparticles using biodegradable polymers (Chitosan and Eudragit RS 100) by emulsion droplet coalescence method. The model drug used here is 5-fluorouracil which is a pyrimidine analogue that is mainly used to treat colonic carcinoma, under the category of anti-neoplastic drugs. Tween 20 was used as emulsifier and colloidal...

Author(s): Y. Dastagiri Reddy, D. Dhachinamoorthi and K. B. Chandra sekhar

June 2013

In vitro anthelmintic potential and phytochemical composition of ethanolic and aqueous crude extracts of Zanthoxylum chalybeum Engl.

Development of helminthes resistance to chemotherapeutic drugs coupled with high costs and misuse of conventional drugs call for the search of medicinal plants as alternative source of helminthes control. In vitro studies were conducted to determine the anthelmintic activity and phytochemical compounds of Zanthoxylum chalybeum. Bioassay was conducted using 70% ethanol and aqueous extracts’...

Author(s): A. S. Nalule, J. M. Mbaria and J. W. Kimenju