September 2013
Formulation and evaluation of captopril floating matrix tablets based on gas formation
Captopril has a short elimination half-life and is stable at pH 1.2 and as the pH increases; the drug becomes unstable and undergoes a degradation reaction. The purpose of this study was to develop a gastroretentive controlled release drug delivery system with swelling and floating properties. Seventeen tablet formulations were designed using hydroxyl propyl methyl cellulose (HPMC) K4M, Carbomer 934, Eudragit RS PO as...
September 2013
Flavonoid and saponin rich fractions of kiwi roots (Actinidia arguta (Sieb.et Zucc.) Planch) with antinociceptive and anti-inflammatory effects
The roots of kiwi (Actinidia arguta (Sieb.et Zucc.) Planch) have medicinal uses as anti-tumour, antinociceptive and anti-inflammatory agents. We aimed to evaluate the antinociceptive and anti-inflammatory effects of the major fractions of kiwi roots. The ethanolic extract of the plant roots was partitioned using a liquid–liquid extraction procedure to give five major fractions. Following phytochemical...
September 2013
Flaxseed and quercetin improves anti-inflammatory cytokines level and insulin sensitivity in animal model of metabolic syndrome fructose-fed rats
The purpose of this study was to assess the beneficial effect of quercetin, flaxseed and/or in combination as synergetic, in an animal model of metabolic syndrome (MtS), high fructose (HF)-fed rats. Fifty male Sprague-Dawley rats, 3 months old, weighing between 110 to 120 g were randomly divided into 5 groups. Rats were given drinking water (negative (-ve) control rats) or 10% fructose in drinking water (HF;...
September 2013
Simultaneous determination of saikosaponins in Bupleurum Radix from different locations by high performance liquid chromatography- charged aerosol detection (HPLC-CAD) method and its immunomodulation effects on mouse splenocytes
A high performance liquid chromatography (HPLC)-Charged Aerosol Detection (CAD) was employed to simultaneously determine saikosaponins which include saikosaponin a (SSa), saikosaponin b2 (SSb2) and saikosaponin d (SSd) in Bupleurum Radix from different locations. Meanwhile, MTT assay was used to compare the proliferation effect of SSa, SS and SSb2 on mouse splenocytes, and enzyme linked immunosorbent assay (ELISA)...
September 2013
The contribution of disease and drug related factors to non-compliance with directly observed treatment short-course among tuberculosis patients
Non-compliance with anti-tuberculosis therapy has been cited as a major barrier to the control of TB. There are different factors responsible for the non-compliance of TB. The cross sectional prospective participants in the study were interviewed by using a set of questionnaire. TB patients were enrolled at DOTS Centre of LRS Institute of Tuberculosis and Respiratory Disease, New Delhi, India. Patients who...
September 2013
Protective action of vitamin C against mutagenic effects of synthetic food color tartrazine
The present study has been carried out to investigate the possible mutagenic effects of the synthetic food color tartrazine on mitosis, deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) contents of Allium cepa roots and protein banding pattern of A. cepa seeds. The obtained results indicated that the synthetic food color tartrazine (E102) had the ability to cause different mitotic changes...
September 2013
Chemopreventive potential of methanol extract of Dicranopteris linearis leaf on DMBA/croton oil-induced mouse skin carcinogenesis
The present study was carried out to elucidate the chemopreventive potential of methanol extract of Dicranopteris linearis (MEDL) in a two-stage mouse skin carcinogenesis model due to the interrelated inflammation, oxidative stress and tumor promotion pathways. MEDL was prepared in a dose range of 30 to 300 mg/kg body weight. A total of 48 imprinting control region (ICR) female mice (6 to 8 weeks old) were...
September 2013
Evaluating the in silico activity of bioactive compound iressa, tarceva and capsaicin against epidermal growth factor receptor tyrosine kinase
Epidermal growth factor receptor (EGFR) protein tyrosine kinases (PTKs) are known for their role in cancer. Lapatinib drug have been reported to be the molecules of interest, with potent anticancer activity and they act by binding to adenosine triphosphate (ATP) site of protein kinases. ATP binding site of protein kinases provides an extensive opportunity to design newer analogs. Here we aimed to do the molecular...
September 2013
Enhanced selectivity approach for fast analysis of enalaprilat, lisinopril and benazepril in pharmaceutical dosage forms and spiked human plasma by ion chromatography
A simple and highly selective method for determination of enalaprilat (ENT), lisinopril (LSP) and benazepril hydrochloride (BZP) in pharmaceutical dosage forms as well as spiked human plasma by ion chromatography with UV detection has been developed. ENT and LSP are compounds with little inherent hydrophobicity that make their analysis using HPLC essentially sophisticated necessitating either complex extraction...
September 2013
Formation of polymeric films containing supersaturated levonorgestrel contraceptive drug by transdermal metered dose aerosol
Due to the benefits of transdermal sprays, formulation of levonorgestrel as a transdermal metered dose aerosol was studied in this work. Simultaneously, super-saturation was evaluated as an effective method to increase the transfer of active ingredients to the skin. By using anti-nucleant polymers and solvent evaporation...
September 2013
Eugenol-rich essential oil of Anthemis mazandranica and its antibacterial activities
The hydro-distilled volatile oil obtained from aerial parts of Anthemis mazandranica was analyzed by gas chromatography and mass spectrometry (GC-MS). Seventeen compounds were identified, representing 93.35% of the total oil composition, with eugenol (35.5%) being the main component. Oil antimicrobial activity was carried out using the disk diffusion and minimal inhibitory concentration (MIC). The best...
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