African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 22 September, 2013; 7(35)

September 2013

Flaxseed and quercetin improves anti-inflammatory cytokines level and insulin sensitivity in animal model of metabolic syndrome fructose-fed rats

The purpose of this study was to assess the beneficial effect of quercetin, flaxseed and/or in combination as synergetic, in an animal model of metabolic syndrome (MtS), high fructose (HF)-fed rats. Fifty male Sprague-Dawley rats, 3 months old, weighing between 110 to 120 g were randomly divided into 5 groups. Rats were given drinking water (negative (-ve) control rats) or 10% fructose in drinking water (HF;...

Author(s): Hala M. Abdelkarem, and Lila H. Fadda

September 2013

Formulation and evaluation of captopril floating matrix tablets based on gas formation

Captopril has a short elimination half-life and is stable at pH 1.2 and as the pH increases; the drug becomes unstable and undergoes a degradation reaction. The purpose of this study was to develop a gastroretentive controlled release drug delivery system with swelling and floating properties. Seventeen tablet formulations were designed using hydroxyl propyl methyl cellulose (HPMC) K4M, Carbomer 934, Eudragit RS PO as...

Author(s): Rayehe Teymouri Rad, Zahra Jafari-Azar and Seyed Alireza Mortazavi,

September 2013

Flavonoid and saponin rich fractions of kiwi roots (Actinidia arguta (Sieb.et Zucc.) Planch) with antinociceptive and anti-inflammatory effects

The roots of kiwi (Actinidia arguta (Sieb.et Zucc.) Planch) have medicinal uses as anti-tumour, antinociceptive and anti-inflammatory agents. We aimed to evaluate the antinociceptive and anti-inflammatory effects of the major fractions of kiwi roots. The ethanolic extract of the plant roots was partitioned using a liquid–liquid extraction procedure to give five major fractions. Following phytochemical...

Author(s): Kun Teng, Hong-Sheng Ruan and Hai-Feng Zhang

September 2013

Simultaneous determination of saikosaponins in Bupleurum Radix from different locations by high performance liquid chromatography- charged aerosol detection (HPLC-CAD) method and its immunomodulation effects on mouse splenocytes

A high performance liquid chromatography (HPLC)-Charged Aerosol Detection (CAD) was employed to simultaneously determine saikosaponins which include saikosaponin a (SSa), saikosaponin b2 (SSb2) and saikosaponin d (SSd) in Bupleurum Radix from different locations. Meanwhile, MTT assay was used to compare the proliferation effect of SSa, SS and SSb2 on mouse splenocytes, and enzyme linked immunosorbent assay (ELISA)...

Author(s): Lina Wang, Bin Chen, Wei Wang, Nan Xu and Tianzhu Jia

September 2013

The contribution of disease and drug related factors to non-compliance with directly observed treatment short-course among tuberculosis patients

Non-compliance with anti-tuberculosis therapy has been cited as a major barrier to the control of TB. There are different factors responsible for the non-compliance of TB. The cross sectional prospective participants in the study were interviewed by using a  set of questionnaire. TB patients were enrolled at DOTS Centre of LRS Institute of Tuberculosis and Respiratory Disease, New Delhi, India. Patients who...

Author(s): Md. Salahuddin Ansari, Khalid Umar Khayyam, Manju Sharma and Md. Sarfaraz Alam

September 2013

Protective action of vitamin C against mutagenic effects of synthetic food color tartrazine

The present study has been carried out to investigate the possible mutagenic effects of the synthetic food color tartrazine on mitosis, deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) contents of Allium cepa roots and protein banding pattern of A. cepa seeds. The obtained results indicated that the synthetic food color tartrazine (E102) had the ability to cause different mitotic changes...

Author(s): Hala Mahfouz and Salha Al-Shammrani

September 2013

Chemopreventive potential of methanol extract of Dicranopteris linearis leaf on DMBA/croton oil-induced mouse skin carcinogenesis

The present study was carried out to elucidate the chemopreventive potential of methanol extract of Dicranopteris linearis (MEDL) in a two-stage mouse skin carcinogenesis model due to the interrelated inflammation, oxidative stress and tumor promotion pathways. MEDL was prepared in a dose range of 30 to 300 mg/kg body weight. A total of 48 imprinting control region (ICR) female mice (6 to 8 weeks old) were...

Author(s): R. Rodzi, Y. L Cheah, K. K. Ooi, F. Othman, N. Mohtarrudin, S. F. Tohid, Z. Suhailiand Z. A. Zakaria

September 2013

Evaluating the in silico activity of bioactive compound iressa, tarceva and capsaicin against epidermal growth factor receptor tyrosine kinase

Epidermal growth factor receptor (EGFR) protein tyrosine kinases (PTKs) are known for their role in cancer. Lapatinib drug have been reported to be the molecules of interest, with potent anticancer activity and they act by binding to adenosine triphosphate (ATP) site of protein kinases. ATP binding site of protein kinases provides an extensive opportunity to design newer analogs. Here we aimed to do the molecular...

Author(s): Aristatile Balakrishnan, Abdullah H. Al-Assaf, Wajahatullah Khan, N. Ayyadurai and Zainularifeen Abduljaleel

September 2013

Enhanced selectivity approach for fast analysis of enalaprilat, lisinopril and benazepril in pharmaceutical dosage forms and spiked human plasma by ion chromatography

A simple and highly selective method for determination of enalaprilat (ENT), lisinopril (LSP) and benazepril hydrochloride (BZP) in pharmaceutical dosage forms as well as spiked human plasma by ion chromatography with UV detection has been developed. ENT and LSP are compounds with little inherent hydrophobicity that make their analysis using HPLC essentially sophisticated necessitating either complex extraction...

Author(s): Fawzi Elsebaei, and Yan Zhu

September 2013

Formation of polymeric films containing supersaturated levonorgestrel contraceptive drug by transdermal metered dose aerosol

Due to the benefits of transdermal sprays, formulation of levonorgestrel as a transdermal metered dose aerosol was studied in this work. Simultaneously, super-saturation was evaluated as an effective method to increase the transfer of active ingredients to the skin. By using anti-nucleant polymers and solvent evaporation...

Author(s): Hoseini F, Vatanara A, Moazeni E, Ahmadi F, Darabi M, Gilani K and Rouholamini Najafabadi A

September 2013

Eugenol-rich essential oil of Anthemis mazandranica and its antibacterial activities

The hydro-distilled volatile oil obtained from aerial parts of Anthemis mazandranica was analyzed by gas chromatography and mass spectrometry (GC-MS). Seventeen compounds were identified, representing 93.35% of the total oil composition, with eugenol (35.5%) being the main component. Oil antimicrobial activity was carried out using the disk diffusion and minimal inhibitory concentration (MIC). The best...

Author(s): Fateme Aboee-Mehrizi, Mohammad Hossein Farjam and Abdolhossein Rustaiyan