December 2018

Preclinical 28 days sub-chronic toxicity study of novel formulation of metoprolol tartrate on albino rats using statistical tool

The experimental study mainly focused on evaluation of sub-chronic oral toxicity of sustained formulation of metoprolol succinate. After the formulation development of multiparticulate sustained release capsules, there was an urgent need to analyze their in vivo bioavailability in healthy normal human volunteers. Prior to use in human population, a subchronic oral toxicity study was performed on Swiss Albino rats, of...

Author(s): Sabahuddin Siddique, Sourav Das, Mohi Iqbal Mohammed Abdul, Syed Ata Ur Rahman, Durdana Lateef, Shubhasis Dan and Anirbandeep Bose