May 2018

Febuxostat in patients with hyperuricemia and severe chronic kidney disease

Febuxostat is a non-purine, selective inhibitor of both isoforms of xanthine oxido-reductase (XOR). Its pharmacokinetics is not dependent on renal clearance, and it may be advantageous in patients with chronic kidney disease (CKD). Although febuxostat is effective in patients with mild-to-moderate CKD, its efficacy and safety in patients with severe CKD remain unclear. This retrospective study included patients with an...

Author(s): Ai Yu Yang  

May 2018

Gamma oryzanol loaded microspheres with improved bioavailability

Gamma oryzanol is a phytosterol that is extracted from rice bran oil. It is an antioxidant that possesses a curative effect for many diseases. Gamma oryzanol is a water insoluble compound supporting the idea that it has a low bioavailability due to low intestinal absorption. In this study, γ-oryzanol was loaded in biodegradable microspheres. Intestinal absorption of γ-oryzanol from microspheres was compared...

Author(s): Malik AL-Qdah, Wafaa Hailat, Houssam R.E.H. Bouchekara and Muhammad Sharjeel Javaid