African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: November 2009; 3(11)

November 2009

Pathogenesis of diabetic kidney disease: Review of cellular aspects of renal lesions

Diabetic kidney disease (diabetic nephropathy) is the most common cause of end-stage renal failure disease in some parts of the world, and is associated with increased cardiovascular mortality and morbidity. This review, based on database resources, was undertaken to review the extracellular and intracellular mechanisms involved in the progression of this disease. Growth factors and, signaling pathways, in addition to,...

Author(s): Mohanad Naji Sahib, Shaymaa Abdalwahed Abdulameer, Noorizan Abd.Aziz and Yahaya Hassan

  • Article Number: 6DE08D436912

November 2009

Influence of etherel and gibberellic acid on carbon metabolism, growth, and alkaloids accumulation in Catharanthus roseus L.

Changes in growth parameters, 14C02 and [U-14C]-sucrose incorporation into the primary metabolic pools and essential oil were investigated in leaves and stems ofCatharanthus roseus L treated with etherel and gibberellic acid (GA). Compared to the control, GA and etherel treatments induced significant phenotypic changes and a decrease in chlorophyll content, carbon assimilation rate, and stomatal conductance....

Author(s): A. Misra, N. K. Srivastava, A. K. Srivastava and  A. Khan

  • Article Number: BABD50136931

November 2009

Antioxidant activity of extracts obtained from residues of nodes leaves stem and root of Egyptian Jatropha curcas

The Egyptian Jatropha crop has been studied for antioxidant activity in ethanol extracts from roots, stem, leaves and nodes. The radical scavenging activity of ethanolic extracts was evaluated with the stable diphenylpicryl-hydrazyl (DPPH) free radical. The antioxidant capacity of the studied organs have been revealed the roots and stem were the strongest in all tests followed by leaves and nodes were the least. All the...

Author(s): G. El Diwani, Sh. El Rafie and S. Hawash

  • Article Number: 587BF0936964

November 2009

Toxicological implications of aqueous extract of Clematis brachiata Thunb. leaves in male Wistar rats

Aqueous extract of Clematis brachiata Thunb. leaves at the doses of 100, 200 and 400 mg/kg body weight was investigated for its toxic effect in male Wistar rats on days 1, 7 and 21. The extract at all the doses did not significantly (P > 0.05) alter the liver- and kidney-body weight ratio, conjugated bilirubin, total protein, globulin, sodium, potassium, chloride, inorganic phosphorus, calcium ions,...

Author(s): A. J. Afolayan, M. T. Yakubu, J. R. Appidi and M. Mostafa

  • Article Number: 063123536982

November 2009

In vitro inhibitory effects of Hypoxis obtusa and Dicoma anomala on cyp450 enzymes and p-glycoprotein

Herbal medicines have been shown to cause clinically significant interactions with conventional medicines. Herbal medicines can alter the activity of drug-metabolizing enzymes and transporters, potentially resulting in herb-drug interactions. However, such information is generally not yet available for herbal medicines used only in developing nations. The inhibitory effects of crude extracts of Hypoxis...

Author(s): L. Gwaza, A. R. Wolfe, L. Z. Benet, B. J. Guglielmo, T. E. Chagwedera, C. C. Maponga and C. M. Masimirembwa, 

  • Article Number: 91F8ED137010

November 2009

Antimetastatic and antiproliferative activity of methanolic fraction of Jatropha curcas against B16F10 melanoma induced lung metastasis in C57BL/6 mice

The methanolic fraction of Jatropha curcas was studied for its anti-metastatic activity using B16F10 melanoma cells in C57BL/6 mice. Simultaneous administration of methanolic fraction at doses 100 and 200mg/kg, p.o significantly (p< 0.01) inhibited the metastatic colony formation of the melanoma in lungs by 47.54 and 69.52% respectively, with increase in the survival rate of the metastatic tumour...

Author(s): R. Balaji, N. Rekha, M. Deecaraman and L. Manikandan

  • Article Number: 9F7926337027

November 2009

Haemolytic effects and changes in serum enzymes in normal rats exposed to halofantrine hydrochloride overdose

The levels of serum enzymes and haemolytic effects of overdose of halofantrine hydrochloride were determined in adult male rats. The animals were grouped into four groups and were orally administered halofantine hydrochloride in normal saline: 0 mg/kg (control), 4 mg/kg (under-dose), 8 mg/kg (normal dose) and 16 mg/kg (overdose) in three repeated doses at 6 h interval. The changes in serum enzyme levels were determined...

Author(s): Nwangwu Spencer, Adeyekun Felix, Uhunmwangho S. Esosa, Madu Michael, Ofusori David,  Nwangwu Udoka,  Njoya Helen and J. Josiah Sunday 

  • Article Number: E14EC9037061

November 2009

Neutral components in the leaves and seeds of Syzygium cumini

The Syzygium cumini has medicinal importance as an anti-inflammatory, antibacterial, antiulcergenic. The major components of the leaves and seeds have the acid, neutral and phenolic fractions. In this study, the neutral fraction components which form the bulk is  studied in detail and results were presented. The neutral components of the leaves and seeds have been studied by gas-chromatography. A total of...

Author(s): A. Kumar, T. Jayachandran, P. Aravindhan, D. Deecaraman, R. Ilavarasanand N. Padmanabhan

  • Article Number: 5C80E0D37108

November 2009

Effect of aqueous extract of scent leaf (Ocimum gratissimum) on carbon tetrachloride (CCl4) induced liver damage in albino Wister rats

The effect of aqueous leaf extract of Ocimum gratissimum was investigated in rat models of liver injury induced by carbon tetrachloride (CCl4). Treatment of separate groups of rats with 2.5 ml/kg body weight of 5, 10 and 15% aqueous extracts of O. gratissimum for 3 weeks after establishment of CCl4 induced liver damage, resulted in significantly (p < 0.05) less hepatotoxicity than with...

Author(s): E. M. Arhoghro, K. E. Ekpo and G. O. Ibeh

  • Article Number: 752E58637156

November 2009

Effect of lead toxicity on coenzyme Q levels in rat tissues

Lead is a persistent and common environmental contaminant, which chiefly plays a significant role in modern industry. Coenzyme Q acts as electron and proton carrier in mitochondria and functions as an antioxidant in its reduced form (ubiquinol). To investigate the hazardous effects of lead on the coenzyme Q level, rats were injected i.p. with lead acetate (5 mg/kg b.wt. daily for 6 weeks). Our results showed that...

Author(s): Gamil M. Abdallah, El-Sayed M. El-Sayed and Osama M. Abo-Salem

  • Article Number: 25E328F37197

November 2009

Diversity of plants used to treat respiratory diseases in Tubah, northwest region, Cameroon

This study was conducted in Tubah subdivision, Northwest region, Cameroon, aiming at identifying plants used to treat respiratory diseases. A semi-structured questionnaire was used to interview members of the population including traditional healers, herbalists, herb sellers, and other villagers. The plant parts used as well as the modes of preparation and administration were recorded. Fifty four plant species...

Author(s): D. A. Focho, E. A. P. Nkeng, B. A. Fonge, A. N. Fongod, C. N. Muh, T. W.Ndam and A. Afegenui

  • Article Number: 388CAE737233

November 2009

In vitro inhibitory effect of Urera baccifera (L.) Gaudich. extracts against herpes simplex

The inhibitory activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2)in vitro, at non-cytotoxic concentrations of Urera baccifera (L.) Gaudich. extracts have been evaluated. As for the antiviral activity, the maximum non toxic concentration has been established and this concentration has been used in the anti herpes assay, in vitro. Antiviral activity was determined by ...

Author(s): Fernanda Otaviano Martins, Michelle Mendes da Rocha Gomes, Fábio Luis Pereira Nogueira, Gabriel Rocha Martins, Maria Teresa Villela Romanos, Maria Auxiliadora Coelho Kaplan and Fábio de Sousa Menezes.

  • Article Number: D59A00B37262

November 2009

In-vitro antimicrobial activity of Ageratum conyzoides (Linn) on clinical isolates of Helicobacter pylori

The present study evaluates the antimicrobial activity of fractionated extracts ofAgeratum conyzoides in a bid to isolate the active constituents of the plant with anti-Helicobacter pylori activity. Helicobacter pylori was isolated from the specimens following standard microbiology procedures and isolates subjected to pure fractions of plant extracts for antimicrobial assays. Extracts of A....

Author(s): R. N. Ndip, A. N. Ajonglefac, T. Wirna, H. N. Luma, C. Wirmum and S. M. N.  Efange

  • Article Number: A4AD20537356

November 2009

Evaluation of anti-athletic fatigue activity of Schizandra chinensis aqueous extracts in mice

To study the anti-athletic fatigue effects of Schizandra chinensis aqueous extracts (SCAE), Forty Kunming male mice were randomized into 5 groups (CG, LDG, MDG, IHDG and HDG) equally based on body mass after one week adoption. The control group (CG) was given distilled water and LDG, MDG, IHDG and HDG were given various doses of SCAE (15, 30, 50 and 80 mg/kg) for 28 consecutive days, respectively. Swimming...

Author(s): Shehua Cao, Huanping Shang, Weibing Wu, Jingrong Du and Ramesh Putheti

  • Article Number: A74B22D37372