October 2012

Archaebacterial ancestor of eukaryotes and mitochondriogenesis

Division of the ancestral prokaryotic genome into two circular double-stranded deoxyribonucleic acid (DNA) molecules by genetic recombination, is a basis for the future separate evolution of the nuclear and mitochondrial gene compartment. This suggests monophyletic origin of both mitochondrion and nucleus. Presumed organism which genome undergoes genetic recombination has to be searched among an aerobic, oxygen...

Author(s): Milanko Stupar, Vitomir Vidović, Dragomir Lukač and Ljuba Štrbac

October 2012

Role of proteases in cancer: A review

Proteases in normal cells are important in carrying out biological processes. In living systems, a balance between proteases and their anti-proteases occur, and disturbance of balance leads to many diseases like cancer. Steps starting from tumor initiation, growth, metastasis and finally invasion into some other site involve all five classes of proteases: serine, cysteine, aspartate, threonine and matrix...

Author(s): Syed Rakashanda, Farukh Rana, Shaista Rafiq, Akbar Masood and Shajrul Amin