Clinical Reviews and Opinions

  • Abbreviation: Clin. Rev. Opinions
  • Language: English
  • ISSN: 2141-2553
  • DOI: 10.5897/CRO
  • Start Year: 2009
  • Published Articles: 42


Retrospective analysis of leptospirosis among children – clinico- microbiological and therapeutic aspects for the cases

Nagarajan Prabhu
  • Nagarajan Prabhu
  • Postgraduate and Research Department of Microbiology, Dr. N.G.P. Arts and Science College, An Institution of Kovai Medical Center and Hospital, Coimbatore-641048, India.
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Danialas Joseph Pushpa Innocent
  • Danialas Joseph Pushpa Innocent
  • Division of Microbiology, Rajah Muthaiah Medical College and Hospital, Annamalai University, Chidambaram, India.
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Chinnaswamy Periyasamy
  • Chinnaswamy Periyasamy
  • Institute of Laboratory Medicine, Kovai Medical Center and Hospital, Coimbatore-641048, India.
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  •  Accepted: 01 July 2010
  •  Published: 31 October 2010


These case capsules provide a nice record of the identification of leptospirosis in Coimbatore among children in isolation, sensitive serological analysis and complete haematogram. Eight cases that were clinically suspected showing general body signs (jaundice, decreased urine output and arthralgia) were well studied in this investigation. As per this study, the cases had fever, puffiness, respiratory anguish and hemorrhagic diathesis as leading manifestations. Leptospirosis was suspected in view of the epidemic situation prevailing in the city by conducting a hospital based study on the presence of leptospiral infection among patients with signs/symptoms suggestive of leptospirosis during June 2007 to July 2008. As per this survey, we reported six positive cases among eight clinically suspected cases, of which five survived and one died. It is important to anticipate and recognize the suspected cases early in the course of leptospirosis so that the appropriate steps can be taken to prevent it and to treat it with appropriate antibiotics when it develops.


Key words: Leptospirosis, children, microscopic agglutination test.