February 2015

Evidence of over-dominance for sickle cell trait in a population sample from Buenaventura, Colombia

Sickle cell disease is a hereditary disease caused by a hemoglobin variant, known as hemoglobin S. This hemoglobin variant has a high frequency in areas where malaria is prevalent, because heterozygous genotype has a protective action against malaria infection. We evaluated evidence of over-dominance or deviation from Hardy- Weinberg equilibrium for the HbS gene in Buenaventura, an afro-descendent population with actual...

Author(s): Diana Carolina Ortega Cristian Fong, Heiber Cárdenas and Guillermo Barreto