International Journal of
Medicine and Medical Sciences

  • Abbreviation: Int. J. Med. Med. Sci.
  • Language: English
  • ISSN: 2006-9723
  • DOI: 10.5897/IJMMS
  • Start Year: 2009
  • Published Articles: 526

Full Length Research Paper

Assessment of renal function tests, serum total protein, and lipid profile concentrations among pregnancy-induced hypertension attending women in Asrade Zewudie Memorable Hospital (ASZMPH), Gojjam, Ethiopia: Case-control study

Haymanot Tewabe
  • Haymanot Tewabe
  • Department of Medical Laboratory Sciences, College of Health Science, Addis Ababa University, Ethiopia.
  • Google Scholar
Abebe Edoa
  • Abebe Edoa
  • Department of Medical Laboratory Sciences, College of Health Science, Addis Ababa University, Ethiopia.
  • Google Scholar
Mistire Wolde
  • Mistire Wolde
  • Department of Medical Laboratory Sciences, College of Health Science, Addis Ababa University, Ethiopia.
  • Google Scholar


  •  Received: 03 June 2020
  •  Accepted: 24 September 2020
  •  Published: 30 November 2020

Abstract

Pregnancy-induced hypertension has remained a significant cause of prenatal morbidity and mortality of mothers. So this study aims to assess renal function test, serum total protein, and lipid profile concentrations among pregnancy-induced hypertension women in Asrade Zewudie Memorable hospital (ASZMPH), Gojjam, Ethiopia. A case-control study was done on 200 pregnant women: 100 with pregnancy-induced hypertension (case group) and 100 normotensives (control group) at Asrade Zewudie Memorable Primary hospital Gojjam, Ethiopia from January 24, 2020 to April 30, 2020. 5 ml of venous blood was collected on the SST test tube and analyzed for serum lipid profile, renal function test, and serum total protein. The analysis was done by using SPPS software (version 20.0). The level significance was set at a 95% confidence interval (P-value less than 0.05 was considered clinically significant). In the present study, there was a significant increase in the serum TC, TGs, blood urea, serum creatinine, and LDL (p < 0.05) and a significant decrease in HDL cholesterol in case groups as compared to normal groups (p < 0.05). The elevation of serum total protein was not significant (p >0.05). The outcome of the final multiple logistic regression model indicate that factors like BMI, habits of doing scheduled exercise, habit of drinking alcohol, habit of fruit consumption, trimester and gravidity had significant association with lipid profile tests of the study participants. In the present study, the degree of association between different risk factors selected in multiple logistic regression and lipid profile tests was more significant in case group relative with control group. According to the result of this study, early detection of altered lipid profile and renal function test in preeclamptics showed the incidence of complications can be decreased, which in turn reduces the materno-fetal morbidity and mortality.

Key words: Lipid profile, serum total protein, renal function test, PIH, and Ethiopia

Abbreviation

AOR, Adjusted odd ratio; BMI, body mass index; CDC, Center of Disease Control Center; DBP, diastolic blood pressure; GFR, glomerular filtration rate; HDL, high-density lipoprotein; HDP, hypertension disorder of pregnancy; IQC, internal quality control; LDL, low-density lipoprotein; PIH, pregnancy induced hypertension; SBP, systolic blood pressure; SOPs, standard operating procedures; SST, serum separated tube; TC, total cholesterol; TG, triglyceride; WHO, World Health Organization.