International Journal of
Medicine and Medical Sciences

  • Abbreviation: Int. J. Med. Med. Sci.
  • Language: English
  • ISSN: 2006-9723
  • DOI: 10.5897/IJMMS
  • Start Year: 2009
  • Published Articles: 535

Full Length Research Paper

Effect of the maltodextrin-induced chemical reticulation on the physical properties and healing potential of collagen-based membranes containing Brazilian red propolis extract

Isana Carla Leal Souza
  • Isana Carla Leal Souza
  • Fellow Master degree, Post-Graduation Program in Health and Environment, University Tiradentes, Aracaju/SE, Brazil.
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Marismar Fernandes do Nascimento
  • Marismar Fernandes do Nascimento
  • Fellow Master degree, Post-Graduation Program in Health and Environment, University Tiradentes, Aracaju/SE, Brazil.
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Raquel Gonçalves de Souza Neta
  • Raquel Gonçalves de Souza Neta
  • Department of Biomedicine, University Tiradentes, Aracaju/SE, Brazil.
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José Cleveilton Dos Santos
  • José Cleveilton Dos Santos
  • Department of Denstistry, University Tiradentes, Aracaju/SE, Brazil
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Luiz Pereira Costa4, Juliana Cordeiro Cardoso
  • Luiz Pereira Costa4, Juliana Cordeiro Cardoso
  • Laboratory of synthesis of materials and chromatography, University Tiradentes, Aracaju/SE, Brazil.
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Juliana Cordeiro Cardoso
  • Juliana Cordeiro Cardoso
  • Laboratory of Biomaterials, Department of Pharmacy, University Tiradentes, Aracaju/SE, Brazil.
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Ricardo Luiz Cavalcanti de Albuquerque-Júnior
  • Ricardo Luiz Cavalcanti de Albuquerque-Júnior
  • Morphology and Structural Biology, Department of Medicine, University Tiradentes, Aracaju/SE, Brazil.
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  •  Accepted: 30 September 2013
  •  Published: 31 December 2013

Abstract

The study evaluated the physical properties and healing potential of chemically modified collagen-based membranes containing hydroalcoholic extract of Brazilian red propolis (HERP) in rodents. The collagen chemical modification was carried out through Maillard’s reaction using maltodextrin as reticulant agent, and HERP was incorporated at 0.5%. The HERP-incorporated collagen-based membranes were evaluated regarding the mechanical properties, water vapor permeability and swelling rates. For the wound healing assay, surgical wounds were performed on the back of 100 rats, assigned into five groups (n = 20), whose wounds were dressed as follows: (C) – original membranes; CM – modified membranes; CP – HERP-incorporated original membranes; CMP – HERP-incorporated modified membranes; CTR – undressed wounds (control). Five animals of each group were euthanized at 3, 7, 14 and 21 days and the wounded areas were macroscopic and microscopically analyzed. The CMP-membranes showed lower thickness (p < 0.05), permeability (p < 0.001) and swelling (p < 0.05) than the C-membranes. The CMP-membranes promoted increased wound contraction rates at 3 (p < 0.01), 14 (p < 0.001) and 21 days (p < 0.01) compared to CTR, and provided earlier granulation tissue and cutaneous appendages formation, as well as better organization of the collagen deposition. In conclusion, the CMP-membranes presented advantageous properties to be used as wound dressing and improved wound healing in rodent model.

Key words: Collagen, chemical modification, propolis, wound healing.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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