Abstract

Erythromelalgia is a rare neurovascular peripheral disorder of unknown cause that affects hands or feet causing painful skin redness in affected area. The attacks are periodic and are commonly triggered by heat, pressure, mild activity, exertion, insomnia or stress. Erythromelalgia can occur either as a primary or idiopathic disorder, or as secondary forms associated with hematologic diseases. Drugs have been implicated in several skin disorders but only punctual single cases of erythromelalgia have been related to drug therapies. Here we describe two cases of erythromelalgia associated with penicillin treatment, a new non-described association.

Key words: Erythromelalgia, penicillin, drug