International Journal of
Medicine and Medical Sciences

  • Abbreviation: Int. J. Med. Med. Sci.
  • Language: English
  • ISSN: 2006-9723
  • DOI: 10.5897/IJMMS
  • Start Year: 2009
  • Published Articles: 523

Full Length Research Paper

Human leukocyte antigen (HLA) Cw allele association among psoriasis patients from Western India

U. Shankarkumar
  • U. Shankarkumar
  • National Institute of Immunohaematology, Indian Council of Medical Research 13th Floor, KEM Hospital, Parel, Mumbai – 400012, India.
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A. Shankarkumar
  • A. Shankarkumar
  • National Institute of Immunohaematology, Indian Council of Medical Research 13th Floor, KEM Hospital, Parel, Mumbai – 400012, India.
  • Google Scholar
K. Ghosh
  • K. Ghosh
  • National Institute of Immunohaematology, Indian Council of Medical Research 13th Floor, KEM Hospital, Parel, Mumbai – 400012, India.
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  •  Accepted: 07 December 2011
  •  Published: 22 December 2011

Abstract

 

Psoriasis a common autoimmune disorder characterized by T cell mediated keratinocyte hyperproliferation known to be associated with the presence of certain specific HLA alleles. In this study our aim was to evaluate distribution of Human leukocyte antigen (HLA-Cw) susceptible allele of psoriasis from patients in Western India. The study included 84 Psoriasis patients and 91 normal individuals from the same geographical region. Human leukocyte antigen HLA-C was typed using high resolution polymerase chain reaction- sequence specific oligonucleotide probes (PCR-SSOP) technique. The study revealed significant increase in frequencies of Cw*0202 (OR-6.508, P<0.0001) and Cw*0604 (OR-17.710, P=0.0153) when compared to controls while Cw*1502 (OR-0.130, P=0.0490) were significantly decreased in psoriasis patients. Our study shows a strong association of HLA Cw*0202 and Cw*0604 alleles with psoriasis conferring to its susceptibility to psoriasis patients from Western India.

 

Key words: HLA Cw alleles, Psoriasis, Mumbai, Western India