International Journal of
Medicine and Medical Sciences

  • Abbreviation: Int. J. Med. Med. Sci.
  • Language: English
  • ISSN: 2006-9723
  • DOI: 10.5897/IJMMS
  • Start Year: 2009
  • Published Articles: 535

Full Length Research Paper

Anti-ulcer activity of Rhus coriaria in indomethacin and water immersion restraint induced gastric ulcer in experimental rats

Haqeeq Ahmad*
  • Haqeeq Ahmad*
  • Department of Ilmul-Advia (Pharmacology), National Institute of Unani Medicine, Bangalore-91, Karnataka India.
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Abdul Wadud
  • Abdul Wadud
  • Department of Ilmul-Advia (Pharmacology), National Institute of Unani Medicine, Bangalore-91, Karnataka India.
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Nasreen Jahan
  • Nasreen Jahan
  • Department of Ilmul-Advia (Pharmacology), National Institute of Unani Medicine, Bangalore-91, Karnataka India.
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Izharul Hasan
  • Izharul Hasan
  • Department of Preventive and Social Medicine, Ayurvedic and Unani Tibbia College and Hospital, New Delhi 05, India.
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  •  Received: 11 November 2014
  •  Accepted: 25 March 2015
  •  Published: 27 March 2015

Abstract

The anti-ulcer activity of hydro alcoholic extract of Rhus coriaria Linn (HAERC) was investigated in indomethacin and water immersion-induced restraint gastric ulcer in wistar rats. The assessment was carried out by using ulcer index, ulcer score and histopathological studies of the specimens. HAERC at doses of 145 and 248 mg/kg given orally produced significant inhibition of the gastric lesions induced by indomethacin and water immersion restraint method, and the results were comparable to the standard treatment regime. We observed that R. coriaria Linn extract exhibits significant anti ulcer activity and thus supports the Unani claims about the drug.

Key words: Rhuscoriaria, indomethacin, water immersion induced ulcer model, ulcer index, postsumaq.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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