International Journal of
Medicine and Medical Sciences

  • Abbreviation: Int. J. Med. Med. Sci.
  • Language: English
  • ISSN: 2006-9723
  • DOI: 10.5897/IJMMS
  • Start Year: 2009
  • Published Articles: 535

Full Length Research Paper

Aminothienoandrostane: novel promising anti-tumor agent

Gamal A. Elmegeed
  • Gamal A. Elmegeed
  • Hormones Department and 3Chemistry of Natural Compounds. National Research Centre, Dokki, Giza, Egypt.
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Mohamed El-Far
Hanaa Mahrous
  • Hanaa Mahrous
  • Hormones Department and 3Chemistry of Natural Compounds. National Research Centre, Dokki, Giza, Egypt.
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Mohamed A. Tantawy
  • Mohamed A. Tantawy
  • Hormones Department and 3Chemistry of Natural Compounds. National Research Centre, Dokki, Giza, Egypt.
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Gamal A. Elmegeed
  • Gamal A. Elmegeed
  • Hormones Department and 3Chemistry of Natural Compounds. National Research Centre, Dokki, Giza, Egypt.
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Mohamed El-Far
  • Mohamed El-Far
  • Division of Biochemistry, Faculty of Science, Mansoura University, Mansoura, Egypt.
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Hanaa Mahrous
  • Hanaa Mahrous
  • Hormones Department and 3Chemistry of Natural Compounds. National Research Centre, Dokki, Giza, Egypt.
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Mohamed A. Tantawy
  • Mohamed A. Tantawy
  • Hormones Department and 3Chemistry of Natural Compounds. National Research Centre, Dokki, Giza, Egypt.
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  •  Accepted: 26 February 2009
  •  Published: 30 April 2009

Abstract

The sensitivity of liver to chemotherapy provides the basis of novel investigational treatment. An amino thienoandrostane derivative was synthesized and tested in vitro for anti-tumor activity against heapto-ma cell lines (HepG2) using MTT assay. Also the in vivo anti-tumor activity was evaluated against Ehrlich ascites carcinoma (EAC). After 24 h of tumor inoculation, the tested compound was adminis-tered intraperitoneal (i.p.) with concentration of 25 mg/kg day after day for 14 days. The effect of amino-thienoandrostane on the growth of transplantable tumor and simultaneous alterations in hematological profile was estimated. Aminothienoandrostane in olive oil induced significantly high cytotoxic effect against HepG2cell line (IC50 = 36). Aminothienoandrostane completely inhibited tumor growth and maintained the hemoglobin content, body weight, and WBCs near normal values and similar to what obtained for standard drug 5-flurouracil which is one of the most commonly used drugs to treat cancers.

Key words: Anti-cancer, androstane, hepatoma (Hep-G2), Ehrlich ascites carcinoma(EAC), cytotoxicity.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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