Prevalence of human herpesvirus 8 infection in Iranian patients with hematological malignancies

Seyed Hamidreza Monavari; Hossein Keyvani; Hamidreza mollaie; Mehdi fazlalipour; Farzin sadeghi; Mostafa Salehi â€“Vaziri; Farah Bokharaei-Salim

doi:10.5897/IJMMS2013.0914

International Journal of
Medicine and Medical Sciences

Abbreviation: Int. J. Med. Med. Sci.
Language: English
ISSN: 2006-9723
DOI: 10.5897/IJMMS
Start Year: 2009
Published Articles: 533

Full Length Research Paper

Prevalence of human herpesvirus 8 infection in Iranian patients with hematological malignancies

Seyed Hamidreza Monavari

Seyed Hamidreza Monavari
Department of Virology and Antimicrobial Resistance Research Center, Tehran University of Medical Sciences, Tehran, Iran.
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Hossein Keyvani

Hossein Keyvani
Department of Virology and Antimicrobial Resistance Research Center, Tehran University of Medical Sciences, Tehran, Iran.
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Hamidreza mollaie

Hamidreza mollaie
Medical Virology, Tehran University of Medical Sciences, Tehran, Iran.
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Mehdi fazlalipour

Mehdi fazlalipour
Medical Virology, Tehran University of Medical Sciences, Tehran, Iran.
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Farzin sadeghi

Farzin sadeghi
Medical Virology, Tehran University of Medical Sciences, Tehran, Iran.
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Mostafa Salehi â€“Vaziri

Mostafa Salehi â€“Vaziri
Medical Virology, Tehran University of Medical Sciences, Tehran, Iran.
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Farah Bokharaei-Salim

Farah Bokharaei-Salim
Department of Virology and Antimicrobial Resistance Research Center, Tehran University of Medical Sciences, Tehran, Iran.
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Article Number - C89DF6C115
Vol.5(4), pp. 206-209 , April 2013
https://doi.org/10.5897/IJMMS2013.0914

Accepted: 17 October 2012
Published: 30 April 2013

Abstract

Human herpesvirus 8 (HHV-8) is a gamma-herpesvirus linked causally to Kaposi’s sarcoma and many malignancies such as multicentric Castleman’s disease, primary effusion lymphoma, some lymphoproliferative diseases and post transplantation bone marrow failure. The aim of this study was to determine the prevalence of HHV-8 infection in patients with malignant hematological diseases. From September, 2009 to April, 2010, 62 patients with hematological diseases were recruited for the study. Five milliliter of ethylenediaminetetraacetic acid (EDTA) anti-coagulated peripheral blood was collected from each subject. The presence of HHV-8 DNA was tested using a real time technology for the sequences from HHV-8 ORF65. The mean age of patients was 33.9 ± 18.0 years. Four of the patients were found to be HHV-8 polymerase chain reaction (PCR) positive using Real time-PCR and viral prevalence was 6.5%. HHV-8 was found in 1 (25%) patient with acute myelogenous leukemia (AML), 3 (75%) patients with chronic myelogenous leukemia (CML), and none was detected in patients with acute lymphoblastic leukemia (ALL) and lymphoma. The results of this study show that patients with malignant hematological diseases may have HHV-8 infection, therefore, it seems that considering HHV-8 infection in patients with hematological malignancies might be beneficial.

Key words: Human herpesvirus 8 (HHV-8), malignant hematological diseases, prevalence, Iran.

Abbreviation

Abbreviations: HHV-8, Human herpesvirus 8; EDTA, ethylenediaminetetraacetic acid; AML, acute myelogenous leukemia; CML, chronic myelogenous leukemia; ALL, acute lymphoblastic leukemia.