International Journal of
Medicine and Medical Sciences

  • Abbreviation: Int. J. Med. Med. Sci.
  • Language: English
  • ISSN: 2006-9723
  • DOI: 10.5897/IJMMS
  • Start Year: 2009
  • Published Articles: 535

Full Length Research Paper

Reproductive function in premenopausal African Blacks with metabolic syndrome: Associations among inhibin B, adipokines, pituitary and sex hormones and sex hormone binding globulin

O. I. Famuyiwa
  • O. I. Famuyiwa
  • Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan 200284, Oyo State, Nigeria.
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D. P. Bitrus
  • D. P. Bitrus
  • Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan 200284, Oyo State, Nigeria.
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M. A. Charles-Davies
  • M. A. Charles-Davies
  • Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan 200284, Oyo State, Nigeria.
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U. A. Fabian
  • U. A. Fabian
  • Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan 200284, Oyo State, Nigeria.
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A. A. Fasanmade
  • A. A. Fasanmade
  • Department of Medicine, College of Medicine, University of Ibadan, Ibadan 200284, Oyo State, Nigeria.
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J. A. Olaniyi
  • J. A. Olaniyi
  • Department of Haematology, College of Medicine, University of Ibadan, Ibadan 200284, Oyo State, Nigeria.
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O. E. Oyewole
  • O. E. Oyewole
  • Department of Health Promotion and Education, College of Medicine, University of Ibadan, Ibadan 200284, Oyo State, Nigeria.
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M. O. Owolabi
  • M. O. Owolabi
  • Department of Medicine, College of Medicine, University of Ibadan, Ibadan 200284, Oyo State, Nigeria.
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J. R. Adebusuyi
  • J. R. Adebusuyi
  • Medical Social Services Department, University College Hospital, Ibadan 200212, Oyo State, Nigeria.
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O. Hassan
  • O. Hassan
  • Medical Social Services Department, University College Hospital, Ibadan 200212, Oyo State, Nigeria.
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B. M. Ajobo
  • B. M. Ajobo
  • Dietetics Department, University College Hospital, Ibadan 200212, Oyo State, Nigeria.
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M. O. Ebesunun
  • M. O. Ebesunun
  • Department of Chemical Pathology, College of Health Sciences, Olabisi Onabanjo University, Ago-Iwoye 120005, Ogun State, Nigeria.
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K. Adigun
  • K. Adigun
  • General Out Patient Unit, University College Hospital, Ibadan 200212, Oyo State, Nigeria.
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K. S. Akinlade
  • K. S. Akinlade
  • Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan 200284, Oyo State, Nigeria.
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S. U. Okoli
  • S. U. Okoli
  • Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan 200284, Oyo State, Nigeria.
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O. G. Arinola
  • O. G. Arinola
  • Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan 200284, Oyo State, Nigeria.
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E. O. Agbedana
  • E. O. Agbedana
  • Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan 200284, Oyo State, Nigeria.
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  •  Received: 31 March 2016
  •  Accepted: 13 July 2016
  •  Published: 31 August 2016

Abstract

Reproductive dysfunction is associated with metabolic syndrome. Since fertility is highly valued in Africa, preliminary data on the association of metabolic syndrome with indices of reproductive function in premenopausal Nigerian women was provided. Sixty six premenopausal participants (44 with metabolic syndrome and 22 controls) aged 18-45 years were purposely selected for this study. Reproductive history, blood pressure and waist circumference were obtained by standard methods. Fasting blood was obtained for pituitary hormones, adipokines, sex hormone and sex hormone binding globulin, and inhibin B assays by EIA, ELISA and electro-chemiluminiscence. Plasma glucose, triglycerides and high density lipoprotein cholesterol were estimated by enzymatic methods. Free androgen index and oestrogen-testosterone ratio were calculated. Data obtained were statistically significant at P<0.05. All reproductive factors except follicle stimulating hormone and free androgen index levels were similar in both groups (P>0.05). Leptin levels were higher while adiponectin levels were lower in MS group than controls (P<0.05). Reproductive function appears sustained in MS. However, altered adipokines may relate to MS.

Key words: Fertility, leptin, adiponectin, cardiovascular disease, type 2 diabetes mellitus.

Abbreviation

17β-HSD, 17β Hydroxysteroid dehydrogenase; AM, age at menarche; BMI, body mass index; BP, blood pressure; CVD, cardiovascular disease; DBP, diastolic blood pressure; DOP, duration of menstrual period; ELISA, enzyme linked immunosorbent assay; ETR, oestrogen testosterone ratio; FAI, free androgen index; FPG, fasting plasma glucose; FSH, follicle stimulating hormone; HDLC, high density lipoprotein cholesterol; K3 EDTA, ethylene diamine tetraacetic acid; LH, luteinising hormone; LOMC, length of menstrual cycle; MS, metabolic syndrome; NA, number of children alive; NLP, number of live births; NOP, number of pregnancies; NPCT, number of pregnancies carried to term; P, probability; SBP, systolic blood pressure; SHBG, sex hormone binding globulin; T2DM, type 2 diabetes mellitus; WC, waist circumference.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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