International Journal of
Medicine and Medical Sciences

  • Abbreviation: Int. J. Med. Med. Sci.
  • Language: English
  • ISSN: 2006-9723
  • DOI: 10.5897/IJMMS
  • Start Year: 2009
  • Published Articles: 535

Short Communication

Evaluation of pain perception latencies following metabolic alteration of plasma pH

Oyekunle Olanrewaju Akinloye
  • Oyekunle Olanrewaju Akinloye
  • Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, P.M.B. 4000, Ogbomoso, Nigeria.
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Iroko Dorcas Oluwafunke
  • Iroko Dorcas Oluwafunke
  • Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, P.M.B. 4000, Ogbomoso, Nigeria.
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Akinwande Rukayat Kikelomo
  • Akinwande Rukayat Kikelomo
  • Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, P.M.B. 4000, Ogbomoso, Nigeria.
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  •  Accepted: 14 October 2013
  •  Published: 31 December 2013

Abstract

Pain has been a subject of intense and continuous research over the years. Several approaches have been employed in understanding and management of pain ranging from peripheral to central modulation as well as systemic to molecular mechanism of integration. This study is therefore aimed at investigating the role of altered plasma pH in the perception of experimental pain in both chronic and acute model. The results indicated significant (p < 0.05) prolonged nociceptive activity by nerve endings at increasing alkalinity and acidity of the plasma in both models of experimental pain used. In conclusion, plasma condition should be an important consideration in the management of pain because introduction of exogenous substances could shift the homeostatic equilibrium and could eventually affect latency and integration of nociception.

Key words: Alkalosis, acidosis, nociception, homeostasis, plasma.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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