Abstract

Herein we report the development of efficient methods to prepare monodentate, bidentate, tridentate and macrocycle compounds based on pyrazole moieties, with the opportunity to change easily structure, substituents, cavities or all these parameters in the synthesis of huge library compounds. These methods take advantage of the vast number of commercially available starting materials containing functional and aliphatic or aromatic amines. Such as structural and electronic diversity makes these approaches well suited to the production of large arrays of compounds for potential application in medicinal, corrosion or coordination chemistry. 

Key words: Pyrazole, bipyrazole, bis pyrazole, N-donor electron rich, macrocycle.