International Journal of
Physical Sciences

  • Abbreviation: Int. J. Phys. Sci.
  • Language: English
  • ISSN: 1992-1950
  • DOI: 10.5897/IJPS
  • Start Year: 2006
  • Published Articles: 2557

Full Length Research Paper

Three dimensional nuchal translucency ultrasound segmentation using region growing for trisomy 21 early assessment

Lai Khin Wee1,2*, Hum Yan Chai2 and Eko Supriyanto2
1Biomedical Engineering Department, Faculty of Computer Science and Automation, Institute of Biomedical Engineering and Informatics, llmenau University of Technology, 98684, Ilmenau, Thuringia, Germany. 2Department of Clinical Science and Engineering, Faculty of Health Science and Biomedical Engineering, University of Technology, Malaysia, 81310, Skudai, Johor, Malaysia.
Email: [email protected]

  •  Accepted: 08 June 2011
  •  Published: 04 August 2011


Ultrasound prenatal screening has been proposed as a most effective technique for trisomy 21 early assessment. The current practice using B mode conventional ultrasonic images are restricted inter and intra observer variability. Therefore, we proposed three dimensional segmentation techniques for ultrasound marker, nuchal translucency (NT), as a replacement method to existing manual two dimensional NT thickness measurements. The developed generic computing algorithms are integrated with VTK and ITK open-sources libraries. Region growing was implemented with growth criteria and rendered by reconstructed multiplanar view. The findings have proven that the developed algorithm was able to produce consistent three dimensional NT segmentation.


Key words: VTK, ITK, ultrasound, region growing, segmentation, nuchal translucency.


PAPP-A, Pregnancy associated plasma protein A; β-hCG, free beta human chorionic gonadotropin; AFP, maternal alpha-fetoprotein; NT, nuchal translucency;CVS,  chorionic villus sampling; PUBS, percutaneous umbilical cord blood;  VTK,visualization toolkit; ITK, insight toolkit; TCL, tool command language; GUI, graphical user interface.