Abstract

1-benzoyl-3-bromo-2-phenylpropenedinitrile derivative 1 reacted with potassium hydroxide to afford the furan derivatives 4 and 5. The furan derivative 5 reacted with formamide, phenyl isothiocyanate, malononitrile, and trichloroacetonitrile to afford the furo[2,3-d] pyrimidine derivatives 6, 8, 11 and 16 respectively. The reaction of 5 with ethyl cyanoacetate afforded however the furo[2,3-b]pyridine derivative 15. The molluscicidal activity of the synthesized compounds towards Biomphalaria alexanrina snails (the intermediate host of Schistosoma mansoni) was investigated and showed weak to moderate activity.

Key words: 1-benzoyl-3-bromo-2-phenylpropenedinitrile, furans, furo [2, 3-d] pyrimidines.