The in vitro antimicrobial susceptibility of recently isolated uropathogens was investigated using two locally produced brands of antibiotics and one imported brand, in a comparative study to determine their degree of effectiveness and the susceptibility profiles of these uropathogens. Seventy eight (78) bacterial strains containing 12 different species of both Gram negative and Gram positive bacteria were isolated and investigated. Escherichia coli was identified as the leading cause of urinary tract infections being the most isolated uropathogen. The activity of FD was comparable with that of AB (imported) which had the most effective antibacterial activities while those contained in JD were the least effective. Of the 18 different antibiotics employed, fluoroquinolones were the most effective antibiotics against all the bacterial isolates, followed by gentamicin > augmentin > nalidixic acid > nitrofurantoin > chloramphenicol while other antibiotics exhibited varying degree of activities on the bacterial isolates. It was therefore concluded that some locally manufactured antibiotics are as effective as imported brands while fluoroquinolones, augumentin, nitrofurantoin, gentamicin and nalidixic acid could be considered for first-line therapy in UTIs.
Key words: Uropathogens, UTIs, susceptibility, antibiotics, multodiscs.
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