This is a descriptive laboratory based case study carried out in Khartoum state hospitals during the period of June, 2007 to April, 2008. The study aimed to evaluate emergence of ESBL among multi drug resistant Escherichia coli and Klebsiella species causing nosocomial UTI. Hundred strains of multi drug resistant (MDR) E. coli and Klebsiella species causing nosocomial urinary tract infections (UTIs) from two main hospitals from Khartoum (Omdurman teaching hospital and Fedail Hospital) were included in this study. Susceptibility testing was performed against antibiotics commonly used in treatment of urinary tract infections. E. coli,Klebsiella pneumoniae and Klebsiella oxytoca (49, 38 and 13% respectively) were among the studied isolates. β-Lactamase was produced by all isolates; high resistance level for 3rd generation cephalosporin was noticed. ESBLs were detected in high prevalence among all multi drug resistant E. coli and Klebsiellaspecies isolates 53%. All isolates were found sensitive to Imipenem and Meropenem. In this study it’s recommended that developing guidelines for the early phenotypic detection of ESBL in microbiology laboratories and seeking knowledge of antibiotic susceptibility pattern for empirical antibiotic therapy. Further studies about ESBL occurrence among UTIs are also recommended.
Key words: ESBL in Sudan, multi-drug resistant, MDR Escherichia coli, MDRKlebsiella spp, urinary tract infection, beta lactamase.
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