African Journal of
Bacteriology Research

  • Abbreviation: J. Bacteriol. Res.
  • Language: English
  • ISSN: 2006-9871
  • DOI: 10.5897/JBR
  • Start Year: 2009
  • Published Articles: 120

Full Length Research Paper

Studies on antibacterial spectrum of extracts of stem bark of Azadirachta indica A. Juss on some clinical isolates associated with urinary tract infection

Olaoluwa Bolu Success
  • Olaoluwa Bolu Success
  • Department of Biological Sciences, College of Science and Technology, Covenant University Ota, Ogun State, Nigeria.
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Ugboko Harriet
  • Ugboko Harriet
  • Department of Biological Sciences, College of Science and Technology, Covenant University Ota, Ogun State, Nigeria.
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Bobai Mathew
  • Bobai Mathew
  • Department of Microbiology, Faculty of Science, Kaduna State University, Kaduna, Nigeria.
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De Nandita
  • De Nandita
  • Department of Biological Sciences, College of Science and Technology, Covenant University Ota, Ogun State, Nigeria.
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  •  Received: 12 September 2017
  •  Accepted: 05 October 2017
  •  Published: 30 November 2017


Adyanthaya S, Pai V, Jose M (2014). Antimicrobial potential of the extracts of the twigs of Azadirachta indica (Neem): An in vitro study. J. Med. Plants Stud. 2(6):53-57.


Akiyama H, Fujii K, Yamasaki O, Oono T, Iwatsuki K (2001). Antibacterial action of several tannins against Staphylococcus aureus. J. Antimicrob. Chemother. 48(4):487-491.


Aliyu MS, Lawal U, Tijani MB, Doko MHI, Garba I, Kokya HA, Ado SA, Hanwa UA, Ibrahim MM (2009). Phytochemical and Antibacterial Properties of Leaf Extracts of Ipomoea asarifolia. Niger. J. Basic Appl. Sci. 19(2):236-240.


Amer H, Helmy WA, Taie HA (2010). In vitro antitumor and antiviral activities of seeds and leaves Neem (Azadirachta indica) extracts. Int. J. Acad. Res. 2(2):47-51.


Ayo RG, Audu OT, Amupita JO, Uwaiya E (2013). Phytochemical screening and antimicrobial activity of three plants used in traditional medicine in Northern Nigeria. J. Med. Plants Res. 7(5):191-197.


Benson H (2005). Microbiological Applications 9th ed. McGraw Hill Higher Education New York. pp. 299-304.


Boudreau MD, Beland FA (2006). An evaluation of the biological and toxicological properties of Aloe barbadensis (Miller), Aloe vera. Aloe vera. J. Environ. Sci. Health Part C 24(1):103-154.


Chattopadhyay R R, Bhattacharyya SK, Medda C, Chanda S, Bag A (2009). A comparative evaluation of antibacterial potential of some plants used in Indian traditional medicine for the treatment of microbial infections. Braz. Arch. Biol. Technol. 52(5):1123-1128.


Cheesbrough M (2010). District laboratory practice in tropical countries, Part 2, Low Price Edition, Cambridge University Press.


El-Mahmood AM, Ogbonna OB, Raji M (2013). The antibacterial activity of Azadarichta indica (neem) seeds extracts against bacterial pathogens associated with eye and ear infections. J. Med. Plants Res. 4(14):1414-1421.


Emeruwa KC (1982). Antimicrobial substances from Cacaya papaya fruit extracts. J. Nat. Prod. 45(2):123-127.


Gibbons S, Leimkugel J, Oluwatuyi M, Micheal H (2003). Activity of Zanthoxylum clava‐herculis extracts against multi‐drug resistant methicillin‐resistant Staphylococcus aureus. Phytother. Res. 17(3):274-275.


Gonzalez L, Matthew S (1982). Identification of Terpenoids from leaves of Piptocarpha perctora and their biological activities. J. Nat. Prod. 4:495-496.


Harborne JB (1973). Phytochemical methods: A guide to modern technique of plant analysis. Charpman and Hall, London. pp. 1-30.


Heinrich M (2005). Merlin Willcox, Gerard Bodeker, Philippe Rasoanaivo (Eds.), 2004. Traditional Medicinal Plants and Malaria, CRC Press, Boca Raton, FL, USA, p. 431. Foreword by David A. Warrell. Epilogue by Merlin Willcox. Numerous figures and tables, bibliographies, index, glossary of technical terms and abbreviations, Traditional Herbal Medicines for Modern Times, vol. 4, US $99.95/UK£ 60.99, ISBN 0-415-30112-2 (hardcover).


Hol WHG, Vrieling K, Veen JA (2003). Nutrients decrease pyrrolizidine alkaloid concentrations in Senecio jacobaea. New Phytologist 158:175-181.


Hsieh PC, Mau JL, Huang SH (2001). Antimicrobial effect of various combinations of plant extracts. Food Microbiol. 18(1):35-43.


Tuazon CU (2015). 

View Accessed: March, 2015.


Jebashree HS, Kingsley S J, Sathish ES, Devapriya D (2011). Antimicrobial activity of few medicinal plants against clinically isolated human cariogenic pathogens-an in vitro study. International Scholarly Research Notices 2011(2011). 6p.


Jigna P, Chanda S (2006). In vitro antimicrobial activities of extracts of Launaea procumbeus Roxb. (Labiateae), Vitis vinifera al L. (Vitaceae) and Cyperus rotundus L. (Cyperaceae). Afr. J. Biomed. Res. 9(2):89-93.


Karou D, Savadogo A, Canini A, Yameogo S, Montesano C, Simpore J, Colizzi V, Traore AS (2005). Antibacterial activity of alkaloids from Sida acuta. Afr. J. Biotechnol. 4(12):1452-1457.


Kittakoop P, Mahidol C, Ruchirawat S (2014). Alkaloids as important scaffolds in therapeutic drugs for the treatments of cancer, tuberculosis, and smoking cessation. Curr. Top. Med. Chem. 14(2):239-252.


Khattak KF (2012). Microbiological quality assessment of commercially available medicinal plants in Peshawar city, Pakistan. Pak. J. Bot. 44(4):1203-1208.


Khan SA, Aslam J (2008). Study on the effect of neem (Azadirachtaindica) leaves smoke in controlling airborne bacteria in residential premises. Current research in Bacteriology, 1, 6466.


Luciana de C. Tavares, Zanon G, Weber AD, Neto AT, Mostardeiro C P, Ivana BM, Da Cruz, Oliveira RM, Ilha V, Dalcol I I, Morel AF (2014). Structure-activity relationship of benzophenanthridine alkaloids from Zanthoxylum rhoifolium having antimicrobial activity.Public Libr. Sci. 9(5):e97000.


More GK, Tshikalange TE, Lall N, Botha FS, Meyer JJ (2008). Antimicrobial Constituents of Artemisia afra Jacq. ex Wild. against Periodontal Pathogens. J. Ethnopharmacol. 119(3):473-477.


Mourao J A, Viera HF, Ângelo AM, Costa RA, Silva dos Fernandes Vieira RH (2010). Antibacterial effect (in vitro) of Moringa oleifera and Annona muricata against Gram positive and Gram negative bacteria. Revista do Instituto de Medicina Tropical de São Paulo 52(3).


Mwitari PG, Ayeka PA, Ondicho J, Matu EN, Bii CC (2013). Antimicrobial Activity and Probable Mechanisms of Action of Medicinal Plants of Kenya: Withania somnifera, Warbugia ugandensis, Prunus africana and Plectrunthus barbatus. Public Library of Science (PLoS).


Ober D (2003). Chemical ecology of alkaloids exemplified with the pyrrolizidines. In: Romeo JT, editor. Integrative phytochemistry: from ethnobotany to molecular ecology. Amsterdam: Pergamon pp. 203-230.


Ogodo AC, Ekeleme UG (2013). In-vitro antibacterial activity of garlic cloves and ginger rhizomes on food-borne pathogens. Int. J. Basic Appl. Sci. 2(4):387-392.


Panghal M, Kaushal V, Yadav JP (2011). In vitro antimicrobial activity of ten medicinal plants against clinical isolates of oral cancer cases. Ann. Clin. Microbiol. Antimicrob. (10):21.


Pradhan P, Joseph L, Gupta V, Chulet R, Arya H, Verma R, Bajpai A (2009). Saraca asoca (Ashoka): A review. J. Chem. Pharm. Res. 1(1):62-71.


Samanta S, Parua GS, Nandi DK, Pati B R, Mondal KC (2004).Impact of Tannic Acid on the Gastrointestinal Microflora. Microbial Ecol. Health Dis. 16(1):32-34.


Scalbert A (1991). Antimicrobial properties of tannins. Phytochemistry 30:3875-3883.


Sharma A, Chandraker S, Patel VK, Ramteke P (2009). Antibacterial activity of medicinal plants against pathogens causing complicated urinary tract infections. Indian J. Pharm. Sci. 71(2):136.


Silva NCC, Fernandes JA (2010). Biological properties of medicinal plants: a review of their antimicrobial activity. J. Venomous Animals Toxins Trop. Dis. 16(3):402-413.


Sofowara A (1993). Screening plants for bioactive agents. In: medicinal plants and traditional medicine in Africa. (2nd edn.) Spectrum books Ltd. Sunshine house, Ibadan; Nigeria. pp. 81-93


Subapriya R, Nagini S (2005). Medicinal properties of neem leaves: a review. Current Med. Chem. AntiCancer Agents, 5(2): 149-156.


Talwar GP, Raghuvanshi P, Misra R, Mukherjee S, Shah S (1997). Plant immunomodulators for termination of unwanted pregnancy and for contraception and reproductive health. Immunol. Cell Biol. 75(2)


Trease GE, Evans WC (1989). Pharmacognsy. 11th edn. Brailliar Tiridel Can. Macmillian publishers.