February 2014

Spectroscopic approach of the interaction study of ceftriaxone and human serum albumin

Under physiological conditions, interaction between ceftriaxone and human serum albumin was investigated by using fluorescence spectroscopy and ultra violet (UV) absorption spectrum. From spectral analysis, ceftriaxone showed a strong ability to quench the intrinsic fluorescence of human serum albumin (HSA) through a static quenching procedure. The binding constant (k) is estimated as K=1.02× 103 M-1 at 298 K....

Author(s): Abu Teir M. M., Ghithan J., Abu-Taha M. I., Darwish S. M. and Abu-hadid M. M.