July 2013

Epigenetic regulation of PGC1 α in human type 2 diabetes

Type 2 diabetes mellitus (T2DM) is the most common metabolic disease in theworld, reaching epidemic proportions. PPARGC1A mRNA expression is reduced in islets from patients with diabetes 2 and it is influenced by both genetic and epigenetic factor. The epigenetic modification, results as a two fold increase in DNA methylation of the PGC1A promoter of diabetes. This two fold increase in DNA methylation is due to the DNA...

Author(s): Y. Dhanusha Yesudhas

July 2013

Changes in airway resistance with cumulative numbers of cigarettes smoked

This work was performed with smokers of Virginia tobacco cigarettes without taking into consideration brand or type of cigarettes. An experimental study was conducted for the variation of cigarettes number and the increments in airway resistance for both normal and respiratory disordered subjects using body plethysmograph for testing individuals. Seventeen (17) nonsmokers and ten smokers were studied. The investigation...

Author(s): Almaasfeh Sultan