Journal of
Biophysics and Structural Biology

  • Abbreviation: J. Biophys. Struct. Biol.
  • Language: English
  • ISSN: 2141-2200
  • DOI: 10.5897/JBSB
  • Start Year: 2009
  • Published Articles: 22

Table of Content: September 2011; 3(2)

September 2011

Effect of the tannoid enriched fraction of Emblica officinalis on α-crystallin chaperone activity under hyperglycemic conditions in lens organ culture

Chaperone-like activity (CLA) of α-crystallin is known to be compromised in diabetic conditions and associated with cataract formation. Protecting α-crystallin CLA may help in delaying and/or preventing cataracts. In this study, we employed a lens organ culture model to study the effect of hyperglycemia on the CLA of α-crystallin and investigated the protective effect the tannoids...

Author(s): P. Anil Kumar, P. Yadagiri Reddy, P. Suryanarayana and G. Bhanuprakash Reddy

  • Article Number: 85D4DDB10897

September 2011

Modeling and proposed mechanism of two radical scavengers through docking to curtail the action of ribonucleotide reductase

Ribonucleotide reductase (RR) is a ubiquitous cytosolic enzyme required for DNA synthesis and repair in all living cells. Therefore, the crucial role of this enzyme in cell division makes it a potential target for designing drugs that inhibit cell growth for cancer therapy. An increased interest in RR as a target for cancer therapy has been documented since the discovery that human RR is regulated by p53 enzyme and that...

Author(s): Sampath Natarajan and Rita Mathews

  • Article Number: 1A5A0C310908