September 2011

Effect of the tannoid enriched fraction of Emblica officinalis on α-crystallin chaperone activity under hyperglycemic conditions in lens organ culture

Chaperone-like activity (CLA) of α-crystallin is known to be compromised in diabetic conditions and associated with cataract formation. Protecting α-crystallin CLA may help in delaying and/or preventing cataracts. In this study, we employed a lens organ culture model to study the effect of hyperglycemia on the CLA of α-crystallin and investigated the protective effect the tannoids...

Author(s): P. Anil Kumar, P. Yadagiri Reddy, P. Suryanarayana and G. Bhanuprakash Reddy

September 2011

Modeling and proposed mechanism of two radical scavengers through docking to curtail the action of ribonucleotide reductase

Ribonucleotide reductase (RR) is a ubiquitous cytosolic enzyme required for DNA synthesis and repair in all living cells. Therefore, the crucial role of this enzyme in cell division makes it a potential target for designing drugs that inhibit cell growth for cancer therapy. An increased interest in RR as a target for cancer therapy has been documented since the discovery that human RR is regulated by p53 enzyme and that...

Author(s): Sampath Natarajan and Rita Mathews