Abstract

The present study reviews the effect of anticancer drug cisplatin regimens on the renal histopathological and ultrastructure of male rat. The kidney being an essential organ of metabolism and elimination of most of the toxic components, it serves as very important site of attack by various chemical agents including cisplatin, in the form of its activated metabolite. In our study, all the induced alterations revealed acute tubular necrosis along with dilation and slogging of epithelium seen in its light microscopic structure whereas, ultrastructural changes showed absence of microvilli in few sections. Several rounded cisternae of SER and presence of dense chromatin in the nucleus with increased mitochondrial density is also one of the noticeable changes seen after drug treatment. The damage, which is irreversible at certain dose level, might cause potential damage to the organ, which can be overcome by designing proper dose regimen and monitoring and by giving it in combination with anti-cancer drugs.

Key words: Cisplatin, necrosis, kidney

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