Abstract

The aim of the study was to determine the histological and histomorphometrical change of seminiferous tubule in mature and immature wistar rats after usingTribulus terresteris (TT). Twenty male wistar rats were selected and randomly divided into four groups: 1) Mature control group (MCG). 2) Mature experimental group (MEG) (orally received 75 mg/kg TT daily for 14 days). 3) Immature control group (ICG). 4) Immature experimental group (IEG) (orally received 75 mg/kg TT daily for 14 days). The number of leydig cells had increment in experimental group when compared with ICG. Result showed that the thickness of the wall of seminiferous tubule in experimental group significantly increased (P < 0.05). Also, TT treatment groups resulted the accumulation of spermatogenic cells were increased in the seminiferous tubule when compared with control group. In addition, sperm was not observed in ICG but sperm were also observed to increase in the treatment groups. It is concluded that TT may improves the sexual activity, increased testestrone by intensification of leydig cells and may caused early puberty in immature rat.

Key words: Histomorphometrical, rat, seminiferous tubule, Tribulus terresteris.