Journal of
Cell and Animal Biology

  • Abbreviation: J. Cell Anim. Biol.
  • Language: English
  • ISSN: 1996-0867
  • DOI: 10.5897/JCAB
  • Start Year: 2007
  • Published Articles: 260

Full Length Research Paper

Evaluation of the potential of human mesenchymal stem cell engrafted after in utero transplantation in murine model

Groza I.1, Daria Pop2, Cenariu M.1, Pall Emoke1
1Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca Romania. 2University of Medicine and Pharmacy Cluj-Napoca Romania.  
Email: [email protected]

  •  Accepted: 21 December 2011
  •  Published: 31 January 2012

Abstract

Mesenchymal stem cells derived from human placenta (hPMSc) is an important alternative source of adult stem cells. These cells with multilinear capacity represent a biological material important for regenerative medicine. In this study, we established a mouse model for in utero transplantation of hPMCs to investigate if these cells would affect long-term, organ-specific engraftment. Murine model results can be extrapolated in human medicine in the treatment of various diseases.

 

Key words:  Placenta, mesenchymal stem cells, engraftment, in utero transplantation.

Abbreviation

 hPMSc, Human placental mesenchymal stem cells; MHC, major histocompatibility complex; PBS, phosphate-buffered saline; EDTA, ethylenediaminetetraacetic acid; FITC, fluorescein isothiocyanate; FACS, fluorescence-activated cell sorting; MSCs, mesenchymal stem cells; SD,standard deviation; E13.5, 13.5 days embryos; E 20, 20 days embryos.