Mesenchymal stem cells derived from human placenta (hPMSc) is an important alternative source of adult stem cells. These cells with multilinear capacity represent a biological material important for regenerative medicine. In this study, we established a mouse model for in utero transplantation of hPMCs to investigate if these cells would affect long-term, organ-specific engraftment. Murine model results can be extrapolated in human medicine in the treatment of various diseases.
Key words: Placenta, mesenchymal stem cells, engraftment, in utero transplantation.
hPMSc, Human placental mesenchymal stem cells; MHC, major histocompatibility complex; PBS, phosphate-buffered saline; EDTA, ethylenediaminetetraacetic acid; FITC, fluorescein isothiocyanate; FACS, fluorescence-activated cell sorting; MSCs, mesenchymal stem cells; SD,standard deviation; E13.5, 13.5 days embryos; E 20, 20 days embryos.
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