Journal of
Cell and Animal Biology

  • Abbreviation: J. Cell Anim. Biol.
  • Language: English
  • ISSN: 1996-0867
  • DOI: 10.5897/JCAB
  • Start Year: 2007
  • Published Articles: 261

Full Length Research Paper

Effect of inorganic mercury on biochemical parameters in Wister rat

Sameha Merzoug1, Mohamed Lamine Toumi2, Abdelkader Oumeddour3, Nadia Boukhris4, Bruno Baudin5, Abdelkrim Tahraoui2 and Abdelmadjid Bairi2  
1Institut de Biologie, Centre Universitaire d’El Tarf, Algérie. 2Laboratoire de Neuroendocrinologie appliquée, Université Badji Mokhtar, Annaba, Algérie. 3Département de Biologie, Faculté des sciences, Université de Jijel, Algérie. 4Service de médecine interne CHU Ibn Sina, Université Badji Mokhtar, Annaba, Algérie. 5Service de Biochimie A, Hospital of Saint – Antoine, 184 rue de Faubourg Saint – Antoine, 75571 Paris cedex 12, France.
Email: [email protected]

  •  Accepted: 10 November 2009
  •  Published: 31 December 2009


The present study has been carried out to investigate the effect of inorganic mercury (mercuric chloride - HgCl2) exposure on biochemical parameters in adult male rats. 48 rats whose average body weight was about 290 g were included in the experiment. HgCl2, dissolved in distilled water, was administered per os at a dose of 0.25 mg/kg of body weight daily during 15, 30, 45 or 60 days. Rats receiving distilled water were considered as controls. At the end of each treatment period, the corresponding group of animals (both control and intoxicated groups) was euthanized in order to measure plasma glucose, cholesterol, triglycerides, total proteins and urea concentrations, alkaline phosphatase (ALP) activity and hepatic glutathione (GSH) level. Our results showed a significant disturbance of ALP activity and uremia throughout the experiment. Plasma triglycerides, cholesterol and total proteins levels were significantly deteriorated following HgCl2exposure by day 30. HgCl2 also induced a hypoglycemia at days 45 and 60. Hepatic GSH content decreased significantly only at day 45 compared to controls. Our study suggests that HgCl2 is mainly a nephrogenic pollutant and disturbs simultaneously the plasma biochemical profile and the hepatic GSH-related detoxifying system.

Key words: Mercuric chloride, biochemical profile, oxidative stress, nephrotoxicity, hepatotoxicity, rat.