Full Length Research Paper
Abstract
Older patients with type 2 diabetes mellitus have a two- to four-fold increased risk of myocardial infarction. This study aims to determine the association between oxidative stress and advanced glycation end product (AGE). Human serum samples from normal older subjects (n = 31), older diabetic patients without myocardial infarction (n = 33), older diabetic patients with myocardial infarction (n = 32), older non-diabetic with myocardial infarction (n = 30) and normal young subjects (n = 31) were investigated. Positive significant correlation was observed between serum AGE and malondialdehyde in older diabetic and non-diabetic patients with myocardial infarction. Negative significant correlation was observed between AGE and vitamin-E in older diabetic and non-diabetic patients with myocardial infarction. However, malondialdehyde and serum AGE were found to be significantly (P < 0.001) higher in older diabetic and non-diabetic patients with and without myocardial infarction as compared with older control subjects. In contrast to all four older groups, the serum AGE was significantly (P < 0.001) lower in young control subjects. This study revealed that AGE was positively associated with markers of oxidative stress in the older groups.
Key words: Advanced glycation end products, myocardial infarction, diabetes.
Copyright © 2024 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0