Journal of
Clinical Medicine and Research

  • Abbreviation: J. Clin. Med. Res.
  • Language: English
  • ISSN: 2141-2235
  • DOI: 10.5897/JCMR
  • Start Year: 2009
  • Published Articles: 103

Full Length Research Paper

Oxidative stress in myocardial infarction: Advanced glycation end-products causes oxidative stress in older myocardial infarction patients

Anjuman Gul
  • Anjuman Gul
  • Department of Biochemistry, College of Medicine, Kingdom of Saudi Arabia Ministry Of Higher Education Qassim University, P. O. Box 6666, Buraidah 51452, Kingdom of Saudi Arabia.
  • Google Scholar
M. Ataur Rahman
  • M. Ataur Rahman
  • HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
  • Google Scholar
Sadaf Hamid
  • Sadaf Hamid
  • Department of Anatomy, Dow University, Karachi, Pakistan.
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  •  Accepted: 05 February 2013
  •  Published: 28 February 2013

Abstract

Older patients with type 2 diabetes mellitus have a two- to four-fold increased risk of myocardial infarction. This study aims to determine the association between oxidative stress and advanced glycation end product (AGE). Human serum samples from normal older subjects (n = 31), older diabetic patients without myocardial infarction (n = 33), older diabetic patients with myocardial infarction (n = 32), older non-diabetic with myocardial infarction (n = 30) and normal young subjects (n = 31) were investigated. Positive significant correlation was observed between serum AGE and malondialdehyde in older diabetic and non-diabetic patients with myocardial infarction. Negative significant correlation was observed between AGE and vitamin-E in older diabetic and non-diabetic patients with myocardial infarction. However, malondialdehyde and serum AGE were found to be significantly (P < 0.001) higher in older diabetic and non-diabetic patients with and without myocardial infarction as compared with older control subjects. In contrast to all four older groups, the serum AGE was significantly (P < 0.001) lower in young control subjects. This study revealed that AGE was positively associated with markers of oxidative stress in the older groups.

 

Key words: Advanced glycation end products, myocardial infarction, diabetes.