Journal of
Clinical Medicine and Research

  • Abbreviation: J. Clin. Med. Res.
  • Language: English
  • ISSN: 2141-2235
  • DOI: 10.5897/JCMR
  • Start Year: 2009
  • Published Articles: 104

Full Length Research Paper

Comparative study of the effects of single and dual infections of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) in peripheral blood lymphocytes of infected individuals in Ebonyi State, Nigeria

Idioha Jude Chinedu
  • Idioha Jude Chinedu
  • Department of Applied Microbiology Faculty of Biological Sciences Ebonyi State University, P. M. B. 053, Abakaliki Nigeria.
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Iroha Ifeanyichukwu Romanus
  • Iroha Ifeanyichukwu Romanus
  • Institute for Hygiene and Microbiology, Department of Medical Microbiology, Ruhr-University Bochum, 44780 BOCHUM Germany.
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Agbafor Nnenna
  • Agbafor Nnenna
  • Department of Applied Microbiology Faculty of Biological Sciences Ebonyi State University, P. M. B. 053, Abakaliki Nigeria.
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Nwuzo Agabus Chidiebube
  • Nwuzo Agabus Chidiebube
  • Department of Applied Microbiology Faculty of Biological Sciences Ebonyi State University, P. M. B. 053, Abakaliki Nigeria.
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Ezeifeka Gerorge Okey
  • Ezeifeka Gerorge Okey
  • Department of applied Microbiology/ Brewery, Faculty of Natural Sciences, Nnamdi Azikiwe University, P. M. B. 5025 Awka, Anambra State, Nigeria.
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  •  Accepted: 02 May 2010
  •  Published: 30 June 2010

Abstract

A total of 700 blood specimens of patients’ attending hematology units of Federal Medical Centre (FMC), Mile Four Hospital, Ebonyi State University Teaching Hospital (EBSUTH) Abakaliki, Mater Misericodia Hospital Afikpo and Private Medical Laboratory Units in Abakaliki town were serologically screened for the presence of human immunodeficiency virus, (HIV), and hepatitis virus and also assayed for absolute lymphocyte count using the improved neubeur chamber heamocytometric method. Fifty two (7.43%), ninety four (13.42%) and eight (1.14%) individuals were positive for HIV, HBV and HIV/ HBV infections respectively. The range of the mean lymphocyte counts for positive individual were 0.6 ± 0.06 - 0.84  ± 0.04 for HIV, 0.51 ± 0.17 - 0.7 ±  0.11 for HBV and 0.35 ± 0.08 - 0.46 ± 0.18 for HIV / HBV x 109/L respectively. Individuals who were below 10 years of age were mostly affected by HIV (25.0%), HBV (25.0%) and HIV/ HBV (12.5%). Highest rate of multiple sexual partnerships (63.7%) occurred among the age group of 21 - 30 years. Statistical analysis (א2) showed significant relationship between HIV, HBV and HIV/ HBV infections with age. To aid clinical management, the variation of absolute lymphocyte counts may be a guide in monitoring the progression of the diseases.

 

 Key words: HIV, HBV, peripheral blood, lymphocyte count.