Abstract

Electrochemical reduction of flutamide, non-steroidal anti-androgen was studied at different pH and concentrations at a dropping mercury electrode/hanging mercury drop electrode using different polarographic techniques. Differential pulse polarography was used to establish an electroanalytical procedure for the determination of flutamide in pharmaceutical formulations, urine and serum samples. The cathodic peak observed is attributed to the reduction of nitro group and found to be ph dependent and useful for quantitative estimation. The single step reduction wave/peak observed was found to be irreversible and diffusion controlled. The lower standard deviation of 1.58% with the developed procedure sample analysis can be carried out without pre-treatment or extraction or prior separation of the sample before determination.

Key words: Flutamide, differential pulse polarography, pharmaceutical formulations, urine, serum.