Journal of
Clinical Medicine and Research

  • Abbreviation: J. Clin. Med. Res.
  • Language: English
  • ISSN: 2141-2235
  • DOI: 10.5897/JCMR
  • Start Year: 2009
  • Published Articles: 104


Elevation of myocardial creatine kinase in absence of myocardial injury (Case report with literature review)

Yaser Elnahar*, Joseph Daoko, Karim El Kersh, Jennifer C Kam, Chady Sarraf and Fayez Shamoon
Department of Cardiology, Seton Hall University, St. Michael Medical Center, 111 central ave Newark NJ 07102, USA.
Email: [email protected]

  •  Accepted: 25 October 2011
  •  Published: 30 November 2011


Macro enzymes are high molecular mass complexes that consist of normal serum enzymes and protein-immunoglobulins. Creatine kinase (CK) is a muscle enzyme that has three isoenzymes. Two types of macro CK have been described; Macro CK type 1 and macro CK type 2. We report a case where cardiac enzymes were persistently elevated in the absence of myocardial injury. The false elevation was secondary to the presence of macro CK type 1 yielding aberrantly increased CK-MB. Our patient lacked clinical as well as electrocardiographic (EKG) changes to validate myocardial ischemia. Apperception of diagnosing falsely elevated cardiac markers is imperative to avoid unnecessary procedures


Key words: Macro CK, ischemia, myocardial infraction.