Journal of
Cancer Research and Experimental Oncology

  • Abbreviation: J. Cancer Res. Exp. Oncol.
  • Language: English
  • ISSN: 2141-2243
  • DOI: 10.5897/JCREO
  • Start Year: 2009
  • Published Articles: 53

Full Length Research Paper

Preliminary analysis of radiation dose effects to rat femora microstructure using synchrotron radiation computed microtomography

Liebert Parreiras Nogueira
  • Liebert Parreiras Nogueira
  • Nuclear Instrumentation Laboratory / COPPE / UFRJ, P.O. Box 68509, 21945-970, Rio de Janeiro, Brazil.
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Christiano Jorge Gomes Pinheiro
  • Christiano Jorge Gomes Pinheiro
  • Physics Institute / State University of Rio de Janeiro, 20550-900, Rio de Janeiro, Brazil.
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Regina Cély Barroso
  • Regina Cély Barroso
  • Physics Institute / State University of Rio de Janeiro, 20550-900, Rio de Janeiro, Brazil.
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Delson Braz
  • Delson Braz
  • Nuclear Instrumentation Laboratory / COPPE / UFRJ, P.O. Box 68509, 21945-970, Rio de Janeiro, Brazil.
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Carlos Eduardo de Almeida
  • Carlos Eduardo de Almeida
  • Laboratory of Radiological Sciences / State University of Rio de Janeiro, Rio de Janeiro, Brazil.
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Cherley Borba Andrade
  • Cherley Borba Andrade
  • Laboratory of Radiological Sciences / State University of Rio de Janeiro, Rio de Janeiro, Brazil.
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Giuliana Tromba
  • Giuliana Tromba
  • Sincrotrone Trieste SCpA, Strada Statale S.S. 14 km 163.5, 34012 Basovizza, Trieste, Italy.
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  • Article Number - 595259A4068
  • Vol.3(7), pp. 76 - 83, October 2011
  •  Accepted: 09 September 2011
  •  Published: 31 October 2011

Abstract

In this work we investigated the consequences of irradiation in the femur of rats to a radiation dose of 5 Gy. Three different sites in femur specimens were imaged using synchrotron radiation microcomputed tomography to assess trabecular bone microarchitecture: head, distal metaphysis and distal epiphysis. Histomorphometric quantification was extracted directly from the 3D tomographic images using synchrontron radiation. The 3D tomographic images were obtained at the SYnchrotron Radiation for MEdical Physics (SYRMEP) beamline at the Elettra Synchrotron Laboratory in Trieste, Italy. A better understanding of the biological interactions that occur after exposure to photon radiation is needed in order to optimize therapeutic regimens and facilitate development and strategies that decrease radiation-induced side effects in humans. Results showed significant differences between irradiated and non-irradiated mostly in head and distal metaphysis bone sites.

 

Key words: Radiotherapy, microtomography, synchrotron radiation, dose effects, histomorphometry, bone microstructure.