A 49 year old woman was admitted to our hospital with symptoms suggestive of breast cancer. The histological study of the left lumpectomy showed diffuse large B-cell lymphoma of the breast. In addition, the radiological assessment of the disease showed multiple organ involvement by the lymphoma. The patient achieved complete response after 3 cycles of chemotherapy but rapidly developed fatal evolution after the dissemination of the disease up to the central nervous system. This case confirmed the importance of the central nervous system prophylaxis in the situation of multiple extra nodal involvement of the diffuse large B-cell lymphoma.
Key words: Lymphoma, extra-nodal involvement, central nervous system involvement, central nervous system prophylaxis.
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