Journal of
Cancer Research and Experimental Oncology

  • Abbreviation: J. Cancer Res. Exp. Oncol.
  • Language: English
  • ISSN: 2141-2243
  • DOI: 10.5897/JCREO
  • Start Year: 2009
  • Published Articles: 56

Case Report

The popliteal lymph node group as a naturally positioned model for research on lung cancer metastasis

W. I. B. Onuigbo
  • W. I. B. Onuigbo
  • Medical Foundation and Clinic, 8 Nsukka Lane, Box 1792, Enugu 400001, Nigeria.
  • Google Scholar

  •  Accepted: 04 January 2010
  •  Published: 30 September 2010


Lung cancer originates so close to the pulmonary veins that penetration into the blood circulation is naturally assured. Despite such excellent hematogenous opportunities, it is the lymphogenous route that brings about centrifugal lymph node involvement as low down as the abdomen. Therefore, it is hypothesized that the more distant popliteal nodes should be purposively harvested ethically, cut serially, processed technically and examined very minutely after specially staining for both blood and lymph endothelium. This model will probably help to explain nature’s secret, namely, that circulating lung cancer cells are largely ineffective colonizers once lymphoid tissues are located afar.


Key words: Lung cancer, popliteal lymph nodes, metastasis.