Journal of
Diabetes and Endocrinology

  • Abbreviation: J. Diabetes Endocrinol.
  • Language: English
  • ISSN: 2141-2685
  • DOI: 10.5897/JDE
  • Start Year: 2010
  • Published Articles: 59

Full Length Research Paper

Antidiabetic and anti- hyperlipidemic effects of ethanolic extract of Dryopteris dilatata leaves

Akpotu Ajirioghene
  • Akpotu Ajirioghene
  • Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Enugu Campus, Nigeria.
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Celestine Ani
  • Celestine Ani
  • Department of Human Physiology, College of Medicine, Enugu State University of Science and Technology, Parklane, Enugu, Nigeria.
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Choice Nworgu
  • Choice Nworgu
  • Department of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Nigeria.
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Okorie Pamela
  • Okorie Pamela
  • Department of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Nigeria.
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Igwe Uzoma
  • Igwe Uzoma
  • Department of Physiology, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Ebonyi State, Nigeria.
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Jide Uzoigwe
  • Jide Uzoigwe
  • Department of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Nigeria.
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Adeyemo Mercy
  • Adeyemo Mercy
  • Department of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Nigeria.
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Nwaeme Ogochukwu
  • Nwaeme Ogochukwu
  • Department of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Nigeria.
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Obinna Onwujekwe
  • Obinna Onwujekwe
  • Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Enugu Campus, Nigeria.
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  •  Received: 19 August 2018
  •  Accepted: 04 September 2018
  •  Published: 30 September 2018

Abstract

The incidence of diabetes mellitus (DM) is increasing globally and it is a major source of concern. This study was undertaken to assess the antidiabetic effect of the ethanolic leaf extract of Dryopteris dilatata (ELEDD).Thirty adult Wistar rats with body weight (BW) of 120-150 g were randomly assigned to groups of five rats each (n=5). Groups 1 served as normal control; Groups 2-6 were diabetic groups; group 2 served as negative control; group 3 received 50 mg/kg of metformin; 4-6 received 200, 400 and 800 mg/kg of ELEDD respectively. The BW and fasting blood glucose level (FBSL) of the rats were monitored weekly. At the end of the experiment, all the rats were anaesthetized with 25% urethane (sigma- Aldrich) intraperitoneally (I.P) and blood samples were collected by cardiac puncture for biochemical analysis. There was an increase in the BW of the metformin treated group and varying doses of ELEDD. It caused 77.00±15.07% decrease in FBSL; 86.94±34.80% and 248.07±20.56% with respect to 400 and 800 mg/kg of ELEDD. There was a significant (p<0.05) increase in the serum total cholesterol (STC), triglycerides (TG) and low density lipoprotein (LDL-C) as well as decrease in high density lipoproteins (HDL-C). Lipid profile groups treated with ELEDD significantly (p<0.05) decreased in a dose dependent manner .This study has shown that DD has hypoglycemic and hypolipidemic effects.

Key words:  Diabetes, Dryopteris dilatai, hypoglycaemic, hypolipidaemic and phytochemical