Journal of
Diabetes and Endocrinology

  • Abbreviation: J. Diabetes Endocrinol.
  • Language: English
  • ISSN: 2141-2685
  • DOI: 10.5897/JDE
  • Start Year: 2010
  • Published Articles: 65

Full Length Research Paper

Identification of the window period for oxidative stress intervention

Zuolin Zhu
Sino-US Pficker Pharmaceuticals Co., Ltd, 86 Huili Road, Huaibei City, Anhui Province, 235000, China
Email: [email protected]

  •  Accepted: 10 March 2011
  •  Published: 30 April 2011


A window period was proposed for oxidative stress attenuating intervention, which explained controversial results from using an anti-oxidation treatment in chronic disease prevention. In this study, a method is reported for identifying the WPOS using a NIDDM diabetes animal model when using any single oxidative stress biomarker. Abnormal oxidative stress was initiated using streptozotocin, and the concentration of TBARS in plasma was used as the biomarker. The results confirmed the existence of WPOS and revealed a very easy way to identify it.


Key words: Oxidative stress, WPOS, diabetes.