A window period was proposed for oxidative stress attenuating intervention, which explained controversial results from using an anti-oxidation treatment in chronic disease prevention. In this study, a method is reported for identifying the WPOS using a NIDDM diabetes animal model when using any single oxidative stress biomarker. Abnormal oxidative stress was initiated using streptozotocin, and the concentration of TBARS in plasma was used as the biomarker. The results confirmed the existence of WPOS and revealed a very easy way to identify it.
Key words: Oxidative stress, WPOS, diabetes.
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