Journal of
Environmental Chemistry and Ecotoxicology

  • Abbreviation: J. Environ. Chem. Ecotoxicol.
  • Language: English
  • ISSN: 2141-226X
  • DOI: 10.5897/JECE
  • Start Year: 2009
  • Published Articles: 197

Full Length Research Paper

Chlorpyrifos induces hypertension in rats

Alvarez A. Anthon* and Campaña-Salcido A. D.
Faculty of Medicine, University A. of Sinaloa, Mexico.
Email: [email protected]

  •  Published: 02 November 2011



This study using a non-invasive measurement with a working range from 0–300 mm Hg and a silent built-in air pump that ensured automated cuff inflation/deflation at a constant rate blood pressure (BP) demonstrated an initially elevated BP in all treatment groups for several hours after exposure. This parameter was monitored for 3 and 14 days. BP was elevated at 3- and 14 –day exposure, but not heart rate (HR), except at the second day at 500 bpm only with the 25 mg kg-1 dose. The systolic pressure (SBP) increased with the 25 mg kg-1 dose at acute treatment P=<0.001; not only but also the media resulted increased with 5 and 25 mg kg-1, P < 0.007,  increased too at 5 an 25 mg kg-1  and at 14 days of treatment P < 0.001. And the diastolic pressure increased with the 25 mg kg-1 dose at 3-day exposure; P< 0.024, but there was an elevation with 5 and  25 mg kg-1 doses at 14-day exposure; P< 0.001. The media resulted increased with 2.5, 5, and 25 mg kg-1; P< 0.001. Data suggest that the alteration of the regulation of blood pressure may be involved in the effects of CHP on rats.


Key words: Chlorpyrifos, hypertension, toxicity, oral exposure.