Abstract

This study using a non-invasive measurement with a working range from 0–300 mm Hg and a silent built-in air pump that ensured automated cuff inflation/deflation at a constant rate blood pressure (BP) demonstrated an initially elevated BP in all treatment groups for several hours after exposure. This parameter was monitored for 3 and 14 days. BP was elevated at 3- and 14 –day exposure, but not heart rate (HR), except at the second day at 500 bpm only with the 25 mg kg^-1 dose. The systolic pressure (SBP) increased with the 25 mg kg^-1 dose at acute treatment P=<0.001; not only but also the media resulted increased with 5 and 25 mg kg^-1, P < 0.007,  increased too at 5 an 25 mg kg^-1  and at 14 days of treatment P < 0.001. And the diastolic pressure increased with the 25 mg kg^-1 dose at 3-day exposure; P< 0.024, but there was an elevation with 5 and  25 mg kg^-1 doses at 14-day exposure; P< 0.001. The media resulted increased with 2.5, 5, and 25 mg kg^-1; P< 0.001. Data suggest that the alteration of the regulation of blood pressure may be involved in the effects of CHP on rats.

Key words: Chlorpyrifos, hypertension, toxicity, oral exposure.