Journal of
Environmental Chemistry and Ecotoxicology

  • Abbreviation: J. Environ. Chem. Ecotoxicol.
  • Language: English
  • ISSN: 2141-226X
  • DOI: 10.5897/JECE
  • Start Year: 2009
  • Published Articles: 197

Full Length Research Paper

Cadmium-induced changes in mitotic index and genotoxicity on Vigna unguiculata (Linn.) Walp

Thangaraja Amirthalingam
  • Thangaraja Amirthalingam
  • Department of Biotechnology, St. Peter’s University, Avadi, Tamilnadu, India
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Ganesan Velusamy
  • Ganesan Velusamy
  • Centre for Research and P.G. Studies in Botany, Ayya Nadar Janaki Ammal College (Autonomous) Sivakasi, Tamilnadu, India
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Raja Pandian
  • Raja Pandian
  • Centre for Research and P.G. Studies in Botany, Ayya Nadar Janaki Ammal College (Autonomous) Sivakasi, Tamilnadu, India
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Thangaraja Amirthalingam
  • Thangaraja Amirthalingam
  • Department of Biotechnology, St. Peter’s University, Avadi, Tamilnadu, India
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Ganesan Velusamy
  • Ganesan Velusamy
  • Centre for Research and P.G. Studies in Botany, Ayya Nadar Janaki Ammal College (Autonomous) Sivakasi, Tamilnadu, India
  • Search for this author on:
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Raja Pandian
  • Raja Pandian
  • Centre for Research and P.G. Studies in Botany, Ayya Nadar Janaki Ammal College (Autonomous) Sivakasi, Tamilnadu, India
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  •  Accepted: 28 January 2013
  •  Published: 31 March 2013

Abstract

 

The present study is aimed to investigate the effect of Cadmium (Cd) on mitotic index (MI) and DNA damage of Vigna unguiculata. The seedlings were exposed to 2, 4, 6, 8 and 10 mM concentrations of cadmium chloride (CdCl2) for 15 days. The drastic reduction in MI was observed due to Cd toxicity because the mitotic divisions had been with holding when the Cd stress increases. Cd-induced genotoxicity was measured through comet assay. This suggests that increased production of reactive oxygen species (ROS) under Cd toxicity serves as a major source of DNA damage leading to strand breakage, removal of nucleotides and variety of modifications in organic bases of nucleotides.

 

Key words: Genotoxicity, comet assay, mitotic index, Cadmium stress, deoxyribonucleic acid (DNA)damage.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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