Journal of
Infectious Diseases and Immunity

  • Abbreviation: J. Infect. Dis. Immun.
  • Language: English
  • ISSN: 2141-2375
  • DOI: 10.5897/JIDI
  • Start Year: 2009
  • Published Articles: 80

Full Length Research Paper

Widal test case study in Togo: Proposition for a rational use

Edinam AGBENU1,2*, Hervé d’ALMEIDA3, Yaotsè DAGNRA3, Maléwè KOLOU3 and Mireille DAVID3
1FMMP-UL, P. O. Box 1515 Lomé, Togo. 2CHU Tokoin, Microbiology Laboratory, P. O. Box 57 Lome, Togo. 3BIOLIM-FMMP-UL, BP 1515 Lomé, Togo.
Email: [email protected], [email protected]

  • Article Number - 17C6BC95313
  • Vol.3(13), pp. 222-225, November 2011
  •  Accepted: 26 October 2011
  •  Published: 15 November 2011

Abstract

The Widal test is still being used in Togo and the results are labelled “positive” even for only one agglutinin without titration. As a result of that, more and more people claim to have typhoid fever while the clinical state is not suggestive and no bacteriological test is performed. We discuss here the results of 200 patients seen in routine laboratories from November 2005 to April 2006. The agglutinin TO, TH, AO, AH, BO, BH, CO, CH were tested in tube and the titre determined for any positive agglutination. We have put together the result of all the agglutinins to have a complete serological profile toward the pathologic Salmonella . Malaria test was performed and the clinical status of the patient checked. Only 3 patients (1.5%) had the serological profile of an infection toSalmonella typhi, 154 patients had a clear negative profile and 42 patients had an intermediate profile. The 42 intermediate profiles are subjects to interpretation. The various hypotheses to explore were a serological scar of an old infection, a headed infection due to an early antibiotherapy, a cross reaction to Salmonella with another germ having a common antigen O. When the patient was positive to malaria test, the most probable disease was malaria in endemic area because of the cross reactivity. The rate of positive malaria was 100% among the 3 patients with positive profile in Widal test versus 3.9% among the 154 patients negative in Widal test and 26.2% among the 42 patients with intermediate serological profiles. The number of positive results is small, pointing out the weakness of clinical diagnosis preceeding the Widal test. The number of intermediate results is high, raising the need of adequate interpretation and labelling of the Widal test in order to reduce wrong interpretation.

 

Key words: Widal and Felix, typhoid, Salmonella, serology.

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