Abstract

Typhoid fever is an important health menace in India and other developing countries. Human typhoid fever is a severe systemic infection of the reticuloendothelial system caused by the bacterium Salmonella typhi. It was estimated that more than 22 million cases of typhoid fever occur in which 200,000 related deaths occur worldwide each year from S. typhi. Human typhoid is similar to the infection caused by Salmonella typhimurium in mice. In this study antioxidant activity of nitric oxide (NO) and antibiotic were evaluated against the oxidative stress generated by S. typhimurium in mice. Infection of mice with bacteria resulted in decrease in the Glutathione peroxidase (GPx) activity by 26.6%, at day 8, as compared to saline treated control and after treatment with formulated drugs, the GPx activity was slightly decreased by 3.11, 4.70, 31.8 and 1.59% as compared with saline treated control.

Key words: Typhoid, glutathione peroxidase, S. typhimurium.