Journal of
Infectious Diseases and Immunity

  • Abbreviation: J. Infect. Dis. Immun.
  • Language: English
  • ISSN: 2141-2375
  • DOI: 10.5897/JIDI
  • Start Year: 2009
  • Published Articles: 93

Short Communication

Direct antiglobulin test (Coombs’) positive autoimmune hemolytic anemia induced by Epstein-Barr virus infectious mononucleosis in two children

Mehmet Akin*, Özlem Åžahin, Kazim KüçüktaÅŸci, Burçin  Kaya, Ersin Gozkeser, Murat ÇaÄŸlar and Firat ErdoÄŸan
Department of Pediatric Hematology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.
Email: [email protected]

  •  Accepted: 22 December 2010
  •  Published: 31 January 2011


Primary Epstein-Barr virus infection in children is usually asymptomatic, but some children or young adults manifest infectious mononucleosis with typical symptoms of fever, pharyngitis, lymphadenopathy, hepatosplenomegaly and a typical lymphocytosis. The infection caused by Epstein-Barr Virus (EBV) can be followed by immunological complications. One of these is autoimmune hemolytic anemia (AIHA) that it is rare but well known ~1:1000 patients with infectious mononucleosis. Two male patients, aged 2  and 2.5 years old  with autoimmune hemolytic anemia  caused by Epstein-Barr virus admitted to our hospital with pallor, palpitation, fever and scleral icterus. Viral capsid antigen -IgM was positive in both cases, indicating the presence of primary Epstein-Barr virus infection. AIHA risk of EBV infection in the first two weeks  might be considered closely because of life threatening complications such as autoimmune hemolytic anemia.


Key words: Epstein-Barr Virus, coombs positive, autoimmune hemolytic anemia.