Journal of
Infectious Diseases and Immunity

  • Abbreviation: J. Infect. Dis. Immun.
  • Language: English
  • ISSN: 2141-2375
  • DOI: 10.5897/JIDI
  • Start Year: 2009
  • Published Articles: 87

Full Length Research Paper

Progression of disease in a more clinically relevant mouse model of respiratory melioidosis

Thomas R. Laws*, Andrew J. H. Simpson and Michelle Nelson
Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, SP4 0JQ, UK.
Email: [email protected]

  •  Accepted: 22 September 2011
  •  Published: 15 October 2011


In acute and lethal infections, antibiotics reduce mortality and therefore extend the duration of the immune response. The progression of the immune response to acute,Burkholderia pseudomallei K96243 infection, via the aerosol route, in BALB/c mice treated with doxycycline (7 days, daily, orally) was explored. The therapy extended survival and limited bacterial growth in the lungs. After cessation of antibiotic therapy, bacterial numbers resurged. The numbers of phagocytes continued to increase with secondary bacterial growth, while inflammatory cytokine concentrations declined. We propose that this model may be more pertinent for the study of human melioidosis.


Key wordsBurkholderia pseudomallei, respiratory, pulmonary, innate immunity, cytokines, bacteria, leukocytes, neutrophils, macrophages, monocytes, antibiotics, doxycycline.