Journal of
Infectious Diseases and Immunity

  • Abbreviation: J. Infect. Dis. Immun.
  • Language: English
  • ISSN: 2141-2375
  • DOI: 10.5897/JIDI
  • Start Year: 2009
  • Published Articles: 80

Full Length Research Paper

Treatment outcome of newly diagnosed sputum positive adult tuberculosis cases in the context of HIV infection

Olusoji M. Ige1 and Regina E. Oladokun2*
1Department of Medicine, College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria. 2Department of Paediatrics, College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria.
Email: [email protected]

  • Article Number - C57844440040
  • Vol.3(12), pp. 210-217, October 2011
  •  Accepted: 07 October 2011
  •  Published: 29 October 2011

Abstract

Nigeria is one of the highest burdened tuberculosis (TB) countries and HIV co-infection poses a challenge in the control efforts of the national programme. Treatment outcome in newly diagnosed smear positive pulmonary TB cases, associated factors and outcome in relation to HIV infection were determined. A 5-year retrospective cross sectional study was carried out on category 1 TB cases at the University College Hospital, Ibadan, Nigeria. International definitions were used to assess outcome. A total of 857 cases were assessed, 75.6% were within the 20 to 49 years age category and 447 (52.2%) were males. A large percentage (46.8%) had (+) of AFB in the sputum, 24.1% was underweight and 199(23.2%) were HIV positive. The overall treatment success rate was 74.4%, 18(2.1%) defaulted, 22(2.6%) failed treatment and 48(5.6%) died. HIV positive cases were more likely to have treatment failure (10.6% vs.0.2%) and higher mortality (4.9% vs. 0.7%) (p = 0.01). All the defaulted cases were HIV negative. The overall TB treatment success rate was good but fell short of the 85% target. HIV co-infection was associated with a poorer outcome. A more community oriented programme, early identification and treatment of HIV are essential to improve treatment outcome.

                                           

Key words: Pulmonary TB, adults, outcome, DOTS, HIV co-infection, Nigeria.

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