Journal of
Medical Genetics and Genomics

  • Abbreviation: J. Med. Genet. Genomics
  • Language: English
  • ISSN: 2141-2278
  • DOI: 10.5897/JMGG
  • Start Year: 2009
  • Published Articles: 48

Full Length Research Paper

HLA-DQA1 genotyping of Helicobacter pylori associated gastritis patients

Nibras S. Al-Ammar1, Ihsan E. Al-Saimary1*, Saad Sh. Hamadi 2, Ma Luo, Trevor Peterson and Chris Czarnecki
1Department of Microbiology, College of Medicine, University of Basrah, P.O.Box 696, Ashar, Basrah 42001, Iraq. 2Department of Medicine, College of Medicine, University of Basrah, Basrah, Iraq.
Email: [email protected]

  •  Accepted: 20 January 2011
  •  Published: 28 February 2011

Abstract

To study HLA-DQA1 genotyping in Helicobacter pylori associated gastritis patients. This study was carried out in College of Medicine, University of Basrah. HLA-DQA1 genotyping was done in College of Medicine, University of Manitoba, Winnipeg, Canada during the period from 17th of April 2009 to 15th of July 2010. A total of 100 patients (41 males and 59 females and a total of 30 controls (18 males and 12 females) were included in this study. DQA1 alleles frequencies were studied in 70H. pylori associated gastritis patients and 30 healthy controls. DQA1*0201 decreased allele frequency was statistically not significant in H. pylori associated gastritis patients, but there was a strong association (odds ratio= 2.61(, as compared with controls. In the present study many alleles from both locus showed high frequencies with a very strong association, but statistically not significant, this association has not been reported and it is important to note that a larger sample size should be studied.

 

Key words: HLA-DQA1 genotyping, DQA1*0201, Helicobacter

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