Abstract

This work aimed at studying the HLA-DQA1 and HLA-DQB1 genotyping in gastritis patients with positive rapid urease test (RUT). This study was carried out in College of Medicine, University of Basrah. HLA-DQA1 and HLA-DQB1 genotyping was done in College of Medicine, University of Manitoba, Winnpeg, Canada during the period from 17th of April 2009 to 15th of July 2010. A total of 70 gastritis patients (29 males and 41 females) and 30 controls were included in this study. A significant increased frequency of DQA1*050101 and DQB1*020101 alleles was found in individuals (patients + controls) who showed positive rapid diagnostic test (+RDT), but the association was weak (odds ratio = 0.39 and 0.33), as compared with individuals (patients + controls) with (-RDT). A significant decreased frequency of DQB1*050201 allele was found in individuals (patients + controls) with (+RDT). The association was very strong (odds ratio = 5.31), as compared with individuals (patients + controls) with (-RDT). A significant decreased frequencies of DQA1*0201 and DQB1*020101 alleles were found in gastritis patients with (+RDT). The association in DQA1*0201 was very strong (odds ratio = 6.38) and for -DQB1*020101 allele, the association was weak (odds ratio = 0.08), as compared with controls with (RDT). A significant increased frequency of DQA1*0201 allele was found in controls with (+RDT) and the association was very strong (odds ratio = 6.18), as compared with controls with (-RDT). A significant increased frequency of DQB1*020101 allele was found in controls with (+RDT) but with weak association (odds ratio = 0.09), as compared with controls with (-RDT). 

Key Words : HLA-DQA1, HLA-DQB1, DQA1, HLA-DQB1, +RDT, RDT