Abstract

Typhoid fever remains a major health problem in India and other developing countries. It often becomes difficult to precisely estimate the global impact of typhoid, as clinical symptoms resemble many other febrile infections. Salmonella, gram negative bacilli, are facultative intra cellular bacteria and can survive during certain stages of host parasite interaction. There are a number of drugs being used for the treatment of typhoid, but increasing occurrence of multidrug resistant (MDR) strain of Salmonella typhi has complicated its management; thus, it has necessitated the search of formulated drugs for its treatments. Nitric oxide (NO) is a versatile molecule produced in a biological system, it regulates divers array of physiological function and acts as an inter and extra-cellular messenger in most mammalian organ in host’s defense functions for many bacterial infections. Previous studies have suggested that, exogenous administration of L-arginine results in increased NO production, indicating that endogenous substrate is insufficient for maximal NO production. Taking these facts into consideration, it was thought pertinent to see the effect of oral administration of NO donors that is L-arginine, which is one of the semi essential amino acids used as food supplement. Formulation of NO donors and ciprofloxacin are used in low concentrations to reduce toxicity which shows better therapeutic results against experimentally induced Salmonellosis.

Key words: Typhoid, nitric oxide, MDR.